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VPS72 cDNA Clone – Vacuolar Protein Sorting-Associated Protein 72 Homolog Isoform 2

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200834

VPS72 is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. VPS72 may be responsible for binding H2AFZ, which has a role in chromosome segregation.… More details

$245 / 0.01 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
VPS72, cDNA Clone
Full Product Name
VPS72
Product Gene Name
VPS72 cdna clone
Product Synonym Names
CFL1; Swc2; TCFL1; YL-1; YL1
Sequence
Nucleotide Sequence: ATGAGTTTGG CTGGGGGCCG GGCACCCCGG AAGACCGCTG GGAACCGGCT TTCTGGGCTT TTGGAGGCAG AGGAGGAAGA TGAGTTCTAC CAGACGACTT ATGGGGGTTT CACAGAGGAA TCCGGAGATG ATGAGTATCA AGGGGACCAG TCAGACACAG AGGACGAAGT GGACTCTGAC TTTGACATTG ATGAAGGGGA TGAACCATCC AGTGATGGAG AAGCAGAAGA GCCAAGAAGG AAGCGCCGAG TAGTCACCAA GGCCTATAAG GAACCTCTCA AGAGCTTAAG GCCTCGAAAG GTCAACACCC CGGCTGGTAG CTCTCAGAAG GCGCGAGAAG AGAAGGCACT ACTGCCATTA GAACTACAAG ATGACGGCTC TGACAGTCGG AAGTCTATGC GTCAGTCTAC AGCTGAGCAT ACACGACAAA CGTTCCTTCG GGTACAGGAG AGGCAGGGCC AGTCAAGACG GCGAAAGGGG CCCCACTGTG AGCGGCCACT AACCCAGGAG GAACTGCTCC GGGAGGCCAA GATCACAGAA GAGCTTAATT TACGGTCACT GGAGACATAT GAGCGGCTCG AGGCTGATAA AAAGAAGCAG GTTCATAAGA AGCGGAAGTG CCCCGGGCCC ATAATCACCT ATCATTCAGT GACAGTGCCA CTTGTTGGGG AGCCAGGCCC CAAGGAAGAG AACGTTGACA TAGAAGGACT TGATCCTGCT CCCTCGGTGT CTGCATTGAC TCCTCATGCT GGGACTGGAC CCGTCAACCC CCCTGCTCGC TGCTCACGTA CCTTCATCAC TTTTAGTGAT GATGCAACTT TCGAGGAATG GTTCCCCCAA GGGCGGCCCC CAAAAGTCCC TGTTCGTGAG GTCTGTCCAG TGACCCATCG TCCAGCCCTA TACCGGGACC CTGTTACAGA CATACCCTAT GCCACTGCTC GAGCCTTCAA GATCATTCGT GAGGCTTACA AGAAGTACAT TACTGCCCAT GGACTGCCGC CCACTGCCTC AGCCCTGGGC CCCGGCCCGC CACCTCCTGA GCCCCTCCCT GGCTCTGGGC CCCGAGCCTT GCGCCAGAAA ATTGTCATTA AATGA
< br>Transla tion Sequence: MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA PSVSALTPHA GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP GSGPRALRQK IVIK
Form/Format
Lyophilized
Preparation and Storage
Store the plasmid at -20 degree C.
OMIM
600607
3D Structure
ModBase 3D Structure for Q15906
Species
Human
Chromosome Location
1q21
OMIM Reference Number
600607
cDNA Size
1095bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Hind III. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.

Product Categories/Family for VPS72 cdna clone

Epigenetics and Nuclear Signaling

Other Notes

Small volumes of VPS72 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VPS72 purchase

MBS200834 is a cDNA clone targeting VPS72.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS72. It may not necessarily be applicable to this product.

NCBI GI #
5174715
NCBI GeneID
6944
NCBI Accession #
NP_005988.1
UniProt Primary Accession #
Q15906
UniProt Related Accession #
Q15906
GenBank Nucleotide #
NM_005997.2
NCBI Official Full Name
vacuolar protein sorting-associated protein 72 homolog isoform 2
NCBI Official Synonym Full Names
vacuolar protein sorting 72 homolog
NCBI Official Symbol
VPS72
NCBI Official Synonym Symbols
YL1; CFL1; Swc2; YL-1; TCFL1
UniProt Protein Name
Vacuolar protein sorting-associated protein 72 homolog
UniProt Synonym Protein Names
Protein YL-1; Transcription factor-like 1
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS72
UniProt Synonym Gene Names
TCFL1; YL1
UniProt Entry Name
VPS72_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 72 homolog

NCBI Summary for VPS72

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
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UniProt Comments for VPS72

VPS72: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. Belongs to the VPS72/YL1 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; protein complex; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; chromatin modification
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Research Articles on VPS72

1. The 2.7-A-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z alphaC helix.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with VPS72 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with VPS72 and Bone Marrow
 Kidney Antibodies  >1 publications with VPS72 and Kidney
 Bone Antibodies  >1 publications with VPS72 and Bone
 Blood Antibodies  >1 publications with VPS72 and Blood
 Brain Antibodies  >1 publications with VPS72 and Brain
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