WAC cDNA Clone – Ww Domain Containing Adaptor with Coiled-Coil (Human)

The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

WAC: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10p12.1|10p12.1-p11.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: chromatin binding; protein binding

Biological Process: histone monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macroautophagy; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus

Disease: Desanto-shinawi Syndrome