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XYLT2 cDNA Clone – Xylosyltransferase II (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1275697

MBS1275697 is a cDNA clone targeting XYLT2. More details

$965 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
XYLT2, cDNA Clone
Full Product Name
XYLT2 cDNA Clone
Product Gene Name
XYLT2 cdna clone
Sequence
ATGGTGGCGA GCGCGCGAGT GCAGAAGCTG GTGCGGCGCT ACAAGCTGGC GATTGCCACG GCGCTGGCCA TCCTGCTGCT GCAGGGCCTG GTAGTGTGGA GCTTCAGCGG CCTGGAGGAG GACGAGGCGG GCGAGAAAGG AAGGCAGAGG AAGCCACGGC CACTGGACCC TGGCGAAGGT TCCAAGGACA CAGACAGTTC AGCAGGGCGA CGGGGCAGCA CAGGCAGAAG GCATGGGCGC TGGCGGGGCC GTGCTGAGAG CCCAGGAGTG CCCGTGGCCA AGGTGGTACG GGCAGTAACC AGCCGGCAGA GAGCCAGCCG GCGGGTCCCA CCTGCCCCAC CTCCGGAAGC CCCAGGCCGC CAGAACCTGA GTGGGGCAGC AGCTGGGGAG GCGCTGGTAG GGGCAGCTGG CTTCCCACCA CACGGAGATA CAGGGAGCGT GGAGGGCGCC CCCCAGCCCA CGGACAATGG CTTCACCCCC AAGTGCGAGA TCGTGGGCAA GGACGCACTG TCTGCACTGG CCCGGGCCAG CACCAAGCAG TGCCAGCAGG AGATCGCCAA TGTGGTGTGC CTGCACCAGG CTGGGAGCCT CATGCCCAAG GCTGTGCCCC GGCACTGTCA GCTGACTGGG AAGATGAGCC CCGGCATCCA GTGGGATGAG AGCCAAGCCC AGCAGCCCAT GGATGGCCCC CCGGTGCGAA TCGCCTACAT GCTGGTGGTT CACGGCCGCG CCATCCGCCA GCTGAAGCGT CTCCTCAAGG CCGTTTATCA CGAGCAGCAC TTCTTTTACA TCCATGTGGA CAAGCGTTCC GACTACCTGC ACCGGGAGGT GGTGGAGCTG GCCCAGGGCT ATGATAACGT GCGGGTGACG CCCTGGCGCA TGGTTACCAT CTGGGGCGGG GCCAGCCTCC TGACGATGTA CCTGCGGAGC ATGCGGGACC TGCTAGAGGT GCCTGGCTGG GCCTGGGACT TCTTCATCAA CCTCAGTGCC ACTGACTATC CAACCAGGAC CAATGAGGAG CTGGTGGCAT TCCTATCCAA GAACCGGGAC AAGAATTTCC TCAAGTCACA TGGCCGGGAC AACTCCAGGT TCATCAAGAA ACAGGGCCTG GACCGGCTCT TCCATGAGTG CGACTCACAC ATGTGGCGCC TGGGCGAGCG GCAGATCCCA GCAGGCATTG TGGTGGATGG CGGTTCTGAC TGGTTCGTGC TGACACGCAG CTTTGTGGAG TATGTGGTGT ACACAGATGA CCCGCTTGTG GCCCAGCTGC GCCAGTTCTA CACATACACA CTGCTCCCAG CCGAGTCCTT CTTCCACACG GTGCTGGAGA ACAGCCTGGC CTGTGAGACC CTCGTGGACA ACAACCTGCG GGTCACCAAC TGGAACCGCA AGCTGGGCTG CAAGTGCCAG TACAAGCACA TTGTGGACTG GTGTGGCTGC TCCCCCAACG ACTTCAAGCC ACAGGACTTC CTCCGGCTGC AGCAAGTCTC CAGACCCACC TTCTTCGCCC GGAAGTTCGA GTCGACTGTG AACCAGGAGG TGCTGGAAAT CCTGGACTTC CACCTGTACG GCAGCTACCC CCCCGGCACG CCAGCCCTCA AGGCCTACTG GGAGAACACC TACGACGCGG CTGATGGCCC CAGTGGGCTC AGTGATGTCA TGCTCACTGC TTACACAGCC TTCGCCCGCC TCAGCCTGCA CCATGCCGCC ACTGCTGCAC CCCCAATGGG CACCCCACTC TGCAGGTTTG AGCCCAGGGG CTTGCCGTCC AGCGTGCACC TGTATTTCTA TGACGACCAT TTCCAGGGCT ACCTGGTGAC GCAGGCGGTG CAGCCCTCAG CCCAGGGGCC GGCAGAGACG CTTGAGATGT GGCTGATGCC CCAAGGGTCG CTGAAGCTGT TGGGGCGCAG TGACCAGGCC AGCCGGCTCC AGAGTCTGGA GGTTGGCACT GATTGGGACC CCAAAGAGCG TCTTTTCCGG AACTTTGGGG GGTTACTGGG GCCGCTGGAC GAGCCTGTGG CCGTGCAGCG CTGGGCCCGG GGCCCCAACC TCACAGCCAC AGTGGTCTGG ATCGACCCAA CCTATGTGGT GGCCACATCT TATGACATCA CAGTAGATAC GGAGACTGAG GTCACGCAAT ACAAGCCCCC ACTGAGCCGG CCCCTGCGGC CAGGGCCCTG GACTGTTCGA CTCCTTCAGT TCTGGGAACC GCTGGGTGAG ACCCGCTTCC TTGTGCTGCC CTTGACCTTC AACCGCAAAC TACCTCTCAG GAAAGATGAT GCCAGCTGGC TGCACGCAGG GCCACCCCAC AACGAGTACA TGGAGCAGAG TTTCCAGGGC CTGAGTAGCA TCCTGAACCT GCCTCAGCCG GAGCTCGCGG AGGAGGCTGC CCAGCGGCAC ACACAGCTCA CAGGCCCTGC GCTCGAGGCC TGGACAGACA GGGAACTGAG CAGCTTCTGG TCCGTGGCTG GACTGTGTGC CATAGGCCCC TCTCCCTGCC CCTCCCTGGA GCCCTGCAGA CTGACCAGCT GGAGCTCTCT GTCCCCCGAC CCCAAATCAG AGCTGGGGCC TGTCAAAGCA GACGGGCGAC TCAGGTAG
Molecular Weight
71,115 Da
OMIM
264800
Vector
Please Inquire
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of XYLT2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for XYLT2. It may not necessarily be applicable to this product.

NCBI GI #
30354468
NCBI GeneID
64132
NCBI Accession #
BC052262
UniProt Secondary Accession #
Q6UY41; Q86V00
UniProt Related Accession #
Q9H1B5
NCBI Official Full Name
Homo sapiens xylosyltransferase II, mRNA
NCBI Official Synonym Full Names
xylosyltransferase 2
NCBI Official Symbol
XYLT2
NCBI Official Synonym Symbols
SOS; XT2; XT-II; PXYLT2; xylT-II
UniProt Protein Name
Xylosyltransferase 2
UniProt Synonym Protein Names
Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II
Protein Family
Xylosyltransferase
UniProt Gene Name
XYLT2
UniProt Synonym Gene Names
XT2; XT-II; XylT-II
UniProt Entry Name
XYLT2_HUMAN
NCBI Protein Information
xylosyltransferase 2

NCBI Summary for XYLT2

The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
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UniProt Comments for XYLT2

XYLT2: Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Its enzyme activity has not been demonstrated. Belongs to the glycosyltransferase 14 family. XylT subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.2.26; Glycan Metabolism - heparan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 17q21.33

Biological Process: chondroitin sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process

Disease: Pseudoxanthoma Elasticum; Spondyloocular Syndrome
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Research Articles on XYLT2

1. Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with XYLT2 cdna clone

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram

Diseases associated with XYLT2 cdna clone

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with XYLT2 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with XYLT2 and Kidney Diseases
 Fibrosis Antibodies  >2 publications with XYLT2 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with XYLT2 and Disease Models, Animal
 Neurodegenerative Diseases Antibodies  >1 publications with XYLT2 and Neurodegenerative Diseases
 Neoplasm Metastasis Antibodies  >1 publications with XYLT2 and Neoplasm Metastasis
 Autoimmune Diseases Antibodies  >1 publications with XYLT2 and Autoimmune Diseases

Organs/Tissues associated with XYLT2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with XYLT2 and Blood
 Skin Antibodies  >2 publications with XYLT2 and Skin
 Bone Antibodies  >1 publications with XYLT2 and Bone
 Ovary Antibodies  >1 publications with XYLT2 and Ovary
 Kidney Antibodies  >1 publications with XYLT2 and Kidney
 Vascular Antibodies  >1 publications with XYLT2 and Vascular
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