Human ZEB1 cDNA Clone Expression Plasmid – Cat# MBS1274884

ZEB1 cDNA Clone – Zinc Finger E-Box Binding Homeobox 1 (Human)

Name: ZEB1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274884
Price: 1415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274884

MBS1274884 is a cDNA clone targeting ZEB1. More details

$1415 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZEB1, cDNA Clone

Full Product Name

ZEB1 cDNA Clone

Product Gene Name

ZEB1 cdna clone

Sequence

ATGGCGGATG GCCCCAGGTG TAAGCGCAGA AAGCAGGCGA ACCCGCGGCG CAATAACGTT ACAAATTATA ATACTGTGGT AGAAACAAAT TCAGATTCAG ATGATGAAGA CAAACTGCAT ATTGTGGAAG AAGAAAGTGT TACAGATGCA GCTGACTGTG AAGGTGTACC AGAGGATGAC CTGCCAACAG ACCAGACAGT GTTACCAGGG AGGAGCAGTG AAAGAGAAGG GAATGCTAAG AACTGCTGGG AGGATGACAC AGGAAAGGAA GGGCAAGAAA TCCTGGGGCC TGAAGCTCAG GCAGATGAAG CAGGATGTAC AGTAAAAGAT GATGAATGCG AGTCAGATGC AGAAAATGAG CAAAACCATG ATCCTAATGT TGAAGAGTTT CTACAACAAC AAGACACTGC TGTCATTTTT CCTGAGGCAC CTGAAGAGGA CCAGAGGCAG GGCACACCAG AAGCCAGTGG TCATGATGAA AATGGAACAC CAGATGCATT TTCACAATTA CTCACCTGTC CATATTGTGA TAGAGGCTAT AAACGCTTTA CCTCTCTGAA AGAACACATT AAATATCGTC ATGAAAAGAA TGAAGATAAC TTTAGTTGCT CCCTGTGCAG TTACACCTTT GCATACAGAA CCCAACTTGA ACGTCACATG ACATCACATA AATCAGGAAG AGATCAAAGA CATGTGACGC AGTCTGGGTG TAATCGTAAA TTCAAATGCA CTGAGTGTGG AAAAGCTTTC AAATACAAAC ATCACCTAAA AGAGCACTTA AGAATTCACA GTGGAGAGAA GCCATATGAA TGCCCAAACT GCAAGAAACG CTTTTCCCAT TCTGGCTCCT ATAGCTCACA CATAAGCAGT AAGAAATGTA TCAGCTTGAT ACCTGTGAAT GGGCGACCAA GAACAGGACT CAAGACATCT CAGTGTTCTT CACCGTCTCT TTCAGCATCA CCAGGCAGTC CCACACGACC ACAGATACGG CAAAAGATAG AGAATAAACC CCTTCAAGAA CAACTTTCTG TTAACCAAAT TAAAACTGAA CCTGTGGATT ATGAATTCAA ACCCATAGTG GTTGCTTCAG GAATCAACTG TTCAACCCCT TTACAAAATG GGGTTTTCAC TGGTGGTGGC CCATTACAGG CAACCAGTTC TCCTCAGGGC ATGGTGCAAG CTGTTGTTCT GCCAACAGTT GGTTTGGTGT CTCCCATAAG TATCAATTTA AGTGATATTC AGAATGTACT TAAAGTGGCG GTAGATGGTA ATGTAATAAG GCAAGTGTTG GAGAATAATC AAGCCAATCT TGCATCCAAA GAACAAGAAA CAATCAATGC TTCACCCATA CAACAAGGTG GCCATTCTGT TATTTCAGCC ATCAGTCTTC CTTTGGTTGA TCAAGATGGA ACAACCAAAA TTATCATCAA CTACAGTCTT GAGCAGCCTA GCCAACTTCA AGTTGTTCCT CAAAATTTAA AAAAAGAAAA TCCAGTCGCT ACAAACAGTT GTAAAAGTGA AAAGTTACCA GAAGATCTTA CTGTTAAGTC TGAGAAGGAC AAAAGCTTTG AAGGGGGGGT GAATGATAGC ACTTGTCTTC TGTGTGATGA TTGTCCAGGA GATATTAATG CACTTCCAGA ATTAAAGCAC TATGACCTAA AGCAGCCTAC TCAGCCTCCT CCACTCCCTG CAGCAGAAGC TGAGAAGCCT GAGTCCTCTG TTTCATCAGC TACTGGAGAT GGCAATTTGT CTCCTAGTCA GCCACCTTTA AAGAACCTCT TGTCTCTCCT AAAAGCATAT TATGCTTTGA ATGCACAACC AAGTGCAGAA GAGCTCTCAA AAATTGCTGA TTCAGTAAAC CTACCACTGG ATGTAGTAAA AAAGTGGTTT GAAAAGATGC AAGCTGGACA GATTTCAGTG CAGTCTTCTG AACCATCTTC TCCTGAACCA GGCAAAGTAA ATATCCCTGC CAAGAACAAT GATCAGCCTC AATCTGCAAA TGCAAATGAA CCCCAGGACA GCACAGTAAA TCTACAAAGT CCTTTGAAGA TGACTAACTC CCCAGTTTTA CCAGTGGGAT CAACCACCAA TGGTTCCAGA AGTAGTACAC CATCCCCATC ACCTCTAAAC CTTTCCTCAT CCAGAAATAC ACAGGGTTAC TTGTACACAG CTGAGGGTGC ACAAGAAGAG CCACAAGTAG AACCTCTTGA TCTTTCACTA CCAAAGCAAC AGGGAGAATT ATTAGAAAGG TCAACTATCA CTAGTGTTTA CCAGAACAGT GTTTATTCTG TCCAGGAAGA ACCCTTGAAC TTGTCTTGCG CAAAAAAGGA GCCACAAAAG GACAGTTGTG TTACAGACTC AGAACCAGTT GTAAATGTAA TCCCACCAAG TGCCAACCCC ATAAATATCG CTATACCTAC AGTCACTGCC CAGTTACCCA CAATCGTGGC CATTGCTGAC CAGAACAGTG TTCCATGCTT AAGAGCGCTA GCTGCCAATA AGCAAACGAT TCTGATTCCC CAGGTGGCAT ACACCTACTC AACTACGGTC AGCCCTGCAG TCCAAGAACC ACCCTTGAAA GTGATCCAGC CAAATGGAAA TCAGGATGAA AGACAAGATA CTAGCTCAGA AGGAGTATCA AATGTAGAGG ATCAGAATGA CTCTGATTCT ACACCGCCCA AAAAGAAAAT GCGGAAGACA GAAAATGGAA TGTATGCTTG TGATTTGTGT GACAAGATAT TCCAAAAGAG TAGTTCATTA TTGAGACATA AATATGAACA CACAGGTAAA AGACCTCATG AGTGTGGAAT CTGTAAAAAG GCATTTAAAC ACAAACATCA TTTGATTGAA CACATGCGAT TACATTCTGG AGAAAAGCCC TATCAATGTG ACAAATGTGG AAAGCGCTTC TCACACTCTG GGTCTTATTC TCAACACATG AATCATCGCT ACTCCTACTG TAAGAGAGAA GCGGAAGAAC GTGACAGCAC AGAGCAGGAA GAGGCAGGGC CTGAAATCCT CTCGAATGAG CACGTGGGTG CCAGGGCGTC TCCCTCACAG GGCGACTCGG ACGAGAGAGA GAGTTTGACA AGGGAAGAGG ATGAAGACAG TGAAAAAGAG GAAGAGGAGG AGGATAAAGA GATGGAAGAA TTGCAGGAAG AAAAAGAATG TGAAAAACCA CAAGGGGATG AGGAAGAGGA GGAGGAGGAG GAAGAAGTGG AAGAAGAAGA GGTAGAAGAG GCAGAGAATG AGGGAGAAGA AGCAAAAACT GAAGGTCTGA TGAAGGATGA CAGGGCTGAA AGTCAAGCAA GCAGCTTAGG ACAAAAAGTA GGCGAGAGTA GTGAGCAAGT GTCTGAAGAA AAGACAAATG AAGCCTAA

Molecular Weight

122,084 Da

OMIM

189909

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ZEB1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZEB1. It may not necessarily be applicable to this product.

NCBI GI #

86169716

NCBI GeneID

6935

NCBI Accession #

BC112392

UniProt Secondary Accession #

Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68; B4DJV0; B4DUW9; E9PCM7; F5H4I8

UniProt Related Accession #

P37275

NCBI Official Full Name

Homo sapiens zinc finger E-box binding homeobox 1, mRNA

NCBI Official Synonym Full Names

zinc finger E-box binding homeobox 1

NCBI Official Symbol

ZEB1

NCBI Official Synonym Symbols

BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1

UniProt Protein Name

Zinc finger E-box-binding homeobox 1

UniProt Synonym Protein Names

NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8

Protein Family

Zinc finger E-box-binding homeobox

UniProt Gene Name

ZEB1

UniProt Synonym Gene Names

AREB6; TCF8; TCF-8

UniProt Entry Name

ZEB1_HUMAN

NCBI Protein Information

zinc finger E-box-binding homeobox 1

NCBI Summary for ZEB1

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

UniProt Comments for ZEB1

TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: Transcription, coactivator/corepressor; C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p11.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding

Biological Process: cell proliferation; immune response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; regulation of transcription from RNA polymerase II promoter

Disease: Corneal Dystrophy, Fuchs Endothelial, 6; Corneal Dystrophy, Posterior Polymorphous, 3

Research Articles on ZEB1

1. emphasize the key role of ZEB1 in EMT in cultured BCD cells and support the value of ZEB1 inhibition for BCD cell redifferentiation and generation of functional human beta-like cells for cell therapy of diabetes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ZEB1 cdna clone

Products by Pathway	Pathway Diagram
TGF-beta Receptor Signaling Pathway antibodies	TGF-beta Receptor Signaling Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with ZEB1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>274 publications with ZEB1 and Neoplasms
Neoplasm Metastasis Antibodies	>74 publications with ZEB1 and Neoplasm Metastasis
Neoplasm Invasiveness Antibodies	>73 publications with ZEB1 and Neoplasm Invasiveness
Breast Neoplasms Antibodies	>69 publications with ZEB1 and Breast Neoplasms
Disease Progression Antibodies	>48 publications with ZEB1 and Disease Progression
Adenocarcinoma Antibodies	>48 publications with ZEB1 and Adenocarcinoma
Lung Neoplasms Antibodies	>40 publications with ZEB1 and Lung Neoplasms
Lung Diseases Antibodies	>31 publications with ZEB1 and Lung Diseases
Cell Transformation, Neoplastic Antibodies	>29 publications with ZEB1 and Cell Transformation, Neoplastic
Inflammation Antibodies	>17 publications with ZEB1 and Inflammation

Organs/Tissues associated with ZEB1 cdna clone

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>55 publications with ZEB1 and Lung
Embryonic Tissue Antibodies	>43 publications with ZEB1 and Embryonic Tissue
Blood Antibodies	>32 publications with ZEB1 and Blood
Prostate Antibodies	>31 publications with ZEB1 and Prostate
Muscle Antibodies	>28 publications with ZEB1 and Muscle
Eye Antibodies	>27 publications with ZEB1 and Eye
Kidney Antibodies	>25 publications with ZEB1 and Kidney
Vascular Antibodies	>23 publications with ZEB1 and Vascular
Lymph Node Antibodies	>22 publications with ZEB1 and Lymph Node
Liver Antibodies	>17 publications with ZEB1 and Liver