Human ZFPM2 cDNA Clone Expression Plasmid – Cat# MBS1276891

ZFPM2 cDNA Clone – Zinc Finger Protein, Multitype 2 (Human)

Name: ZFPM2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1276891
Price: 1440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276891

MBS1276891 is a cDNA clone targeting ZFPM2. More details

$1440 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZFPM2, cDNA Clone

Full Product Name

ZFPM2 cDNA Clone

Product Gene Name

ZFPM2 cdna clone

Sequence

ATGTCCCGGC GAAAGCAAAG CAAACCCCGG CAGATCAAAC GGCCGCTTGA AGATGCCATT GAAGATGAGG AAGAAGAATG TCCATCAGAG GAAACAGACA TCATCTCCAA AGGAGACTTT CCATTGGAGG AAAGCTTTTC CACAGAATTT GGGCCTGAAA ATCTGAGCTG CGAAGAAGTG GAATACTTTT GTAACAAAGG TGATGATGAA GGAATCCAGG AGACAGCAGA ATCAGATGGG GACACACAGT CAGAGAAACC GGGGCAACCT GGAGTTGAGA CAGACGACTG GGATGGACCA GGAGAGCTGG AGGTGTTTCA GAAAGATGGG GAACGAAAAA TTCAGAGTCG ACAGCAACTT CCAGTGGGAA CAACCTGGGG GCCGTTTCCT GGGAAGATGG ACTTGAATAA TAATTCTTTG AAGACAAAGG CTCAGGTCCC AATGGTGCTG ACTGCTGGTC CCAAGTGGTT GCTGGATGTG ACTTGGCAAG GAGTGGAAGA CAACAAAAAC AACTGCATTG TGTACAGCAA AGGGGGTCAG CTTTGGTGTA CAACTACGAA GGCCATCTCT GAGGGTGAAG AGCTAATTGC CTTTGTGGTG GATTTTGACT CAAGGCTACA AGCTGCCAGT CAGATGACTC TCACAGAAGG GATGTACCCT GCACGCCTGC TGGACTCAAT TCAGCTGCTT CCTCAGCAAG CTGCCATGGC TTCTATTTTG CCCACAGCTA TTGTCAATAA GGATATATTC CCTTGCAAGT CCTGTGGCAT CTGGTATCGG AGTGAGCGGA ATCTGCAGGC CCATTTGATG TACTACTGCA GTGGGAGGCA AAGAGAAGCT GCTCCGGTGT CAGAGGAAAA TGAAGACAGT GCCCATCAGA TTTCCAGCCT GTGCCCCTTC CCACAGTGCA CCAAGAGCTT TTCAAATGCT CGAGCTCTAG AAATGCACCT GAATTCACAC AGTGGAGTGA AAATGGAAGA ATTCCTGCCC CCTGGTGCTA GTCTAAAATG CACCGTCTGT AGCTACACTG CTGATTCCGT GATCAACTTT CACCAACACC TGTTCTCCCA TCTCACTCAA GCTGCCTTCC GATGTAATCA CTGCCATTTC GGCTTCCAGA CTCAGAGGGA GTTATTGCAG CACCAGGAGC TCCATGTCCC TAGCGGCAAA CTTCCCAGAG AAAGTGACAT GGAACACTCT CCAAGTGCAA CTGAAGACAG CTTACAGCCA GCCACAGACT TATTGACCAG AAGCGAACTT CCCCAGAGCC AAAAGGCCAT GCAGACTAAA GATGCGAGCT CTGACACAGA GCTGGACAAG TGTGAGAAAA AGACTCAGCT CTTTCTCACG AACCAGAGAC CAGAGATACA GCCTACAACA AATAAACAAA GCTTTTCTTA CACAAAAATA AAGTCTGAGC CCTCTAGCCC AAGACTTGCC TCATCTCCAG TTCAGCCTAA TATTGGGCCT TCTTTCCCTG TGGGCCCTTT CCTATCTCAG TTTTCTTTCC CCCAAGATAT CACCATGGTC CCTCAAGCTT CAGAGATCTT AGCTAAGATG TCTGAACTGG TGCATCGGCG ACTGAGGCAT GGCAGTAGTA GCTACCCTCC CGTCATTTAC AGCCCTTTGA TGCCCAAGGG GGCTACTTGT TTTGAGTGTA ACATAACATT CAATAATTTG GATAATTATC TAGTGCACAA AAAGCATTAT TGCAGCAGCC GATGGCAGCA GATGGCTAAG TCCCCAGAGT TCCCTAGTGT GTCAGAAAAG ATGCCTGAAG CTTTGAGTCC CAACACTGGC CAAACCTCCA TAAACCTTCT CAACCCAGCT GCTCATTCTG CTGATCCTGA GAATCCACTT CTTCAAACAT CTTGCATCAA TTCTTCCACT GTCTTAGATT TAATTGGGCC AAATGGGAAG GGCCATGACA AGGACTTTTC CACTCAAACT AAGAAGCTCT CCACCTCCAG TAACAATGAT GACAAAATTA ATGGAAAACC TGTTGATGTG AAAAATCCCA GTGTCCCCTT AGTGGATGGG GAAAGTGACC CAAATAAGAC TACCTGTGAA GCTTGCAACA TTACCTTCAG CCGGCACGAA ACATACATGG TCCACAAACA GTATTACTGT GCTACACGCC ACGACCCTCC ACTGAAGAGG TCTGCTTCCA ACAAAGTGCC TGCCATGCAG AGAACCATGC GCACACGCAA GCGCAGAAAG ATGTATGAGA TGTGCCTACC TGAGCAGGAA CAAAGGCCTC CACTGGTTCA GCAGAGATTT CTTGACGTAG CCAACCTCAA TAATCCTTGT ACCTCCACTC AAGAACCCAC AGAAGGGCTA GGAGAGTGCT ACCACCCAAG ATGTGATATC TTTCCAGGAA TTGTCTCTAA ACACTTGGAA ACTTCTCTGA CGATCAACAA GTGTGTTCCA GTTTCCAAAT GTGATACTAC TCATTCCAGT GTTTCCTGCC TAGAGATGGA CGTGCCCATA GATCTCAGCA AAAAGTGTTT ATCTCAGTCT GAGCGGACGA CCACGTCTCC CAAAAGGCTG CTGGACTATC ACGAGTGCAC TGTGTGCAAG ATCAGTTTCA ATAAGGTAGA AAACTATCTG GCCCACAAGC AGAATTTCTG CCCGGTTACT GCACATCAGC GTAATGACCT GGGTCAACTG GACGGCAAAG TGTTTCCGAA TCCAGAAAGC GAACGAAACA GCCCTGATGT CAGCTACGAA AGAAGCATAA TAAAATGTGA GAAAAATGGG AATTTGAAGC AGCCTTCCCC CAATGGAAAC TTATTTTCAT CCCACCTAGC AACCCTGCAA GGCTTGAAGG TCTTTAGTGA AGCTGCTCAG CTCATTGCTA CAAAAGAAGA AAACAGACAT TTGTTTCTTC CACAATGCCT TTACCCTGGA GCAATAAAGA AAGCAAAAGG AGCCGACCAG CTTTCTCCAT ATTATGGAAT CAAGCCAAGT GATTATATTT CTGGTTCTCT TGTCATCCAT AACACTGACA TCGAGCAAAG CAGAAATGCA GAAAATGAAT CTCCTAAAGG CCAGGCTTCC TCAAATGGGT GTGCTGCGCT GAAGAAAGAT TCTCTGCCAT TGTTGCCCAA AAATCGAGGA ATGGTAATAG TGAATGGTGG ACTGAAACAA GATGAGAGAC CTGCTGCCAA CCCACAGCAA GAGAACATTT CCCAGAATCC TCAGCACGAA GACGACCACA AATCTCCCTC GTGGATCTCT GAGAACCCAT TAGCTGCCAA TGAGAATGTC TCACCAGGAA TTCCCTCAGC AGAGGAACAG TTGTCTAGTA TAGCAAAAGG TGTGAATGGT TCCAGCCAGG CTCCAACCAG TGGGAAATAT TGCCGGCTAT GTGATATCCA GTTCAACAAC CTTTCAAACT TTATAACTCA CAAGAAGTTT TATTGCTCAT CACATGCAGC AGAACATGTC AAATGA

Molecular Weight

113,229 Da

OMIM

187500

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ZFPM2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZFPM2. It may not necessarily be applicable to this product.

NCBI GI #

80478269

NCBI GeneID

23414

NCBI Accession #

BC109222

UniProt Secondary Accession #

Q32MA6; Q9NPL7; Q9NPS4; Q9UNI5

UniProt Related Accession #

Q8WW38

NCBI Official Full Name

Homo sapiens zinc finger protein, multitype 2, mRNA

NCBI Official Synonym Full Names

zinc finger protein, FOG family member 2

NCBI Official Symbol

ZFPM2

NCBI Official Synonym Symbols

DIH3; FOG2; SRXY9; ZNF89B; hFOG-2; ZC2HC11B

UniProt Protein Name

Zinc finger protein ZFPM2

UniProt Synonym Protein Names

Friend of GATA protein 2; FOG-2; Friend of GATA 2; hFOG-2; Zinc finger protein 89B; Zinc finger protein multitype 2

Protein Family

Zinc finger protein

UniProt Gene Name

ZFPM2

UniProt Synonym Gene Names

FOG2; ZNF89B; FOG-2; Friend of GATA 2; hFOG-2

UniProt Entry Name

FOG2_HUMAN

NCBI Protein Information

zinc finger protein ZFPM2

NCBI Summary for ZFPM2

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

UniProt Comments for ZFPM2

FOG2: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent. Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3); a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension. Belongs to the FOG (Friend of GATA) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; transcription corepressor activity; transcription factor binding

Biological Process: blood coagulation; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: 46,xy Sex Reversal 9; Diaphragmatic Hernia 3; Tetralogy Of Fallot

Research Articles on ZFPM2

1. ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ZFPM2 cdna clone

Products by Pathway	Pathway Diagram
Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies	Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with ZFPM2 cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>14 publications with ZFPM2 and Cardiovascular Diseases
Hernia, Diaphragmatic Antibodies	>9 publications with ZFPM2 and Hernia, Diaphragmatic
Tetralogy of Fallot Antibodies	>7 publications with ZFPM2 and Tetralogy of Fallot
Neoplasms Antibodies	>6 publications with ZFPM2 and Neoplasms
Diaphragmatic Hernia 3 Antibodies	>4 publications with ZFPM2 and Diaphragmatic Hernia 3
Leukemia, Myeloid Antibodies	>3 publications with ZFPM2 and Leukemia, Myeloid
Nervous System Diseases Antibodies	>3 publications with ZFPM2 and Nervous System Diseases
Leukemia Antibodies	>3 publications with ZFPM2 and Leukemia
Ovarian Neoplasms Antibodies	>2 publications with ZFPM2 and Ovarian Neoplasms
Fibrosis Antibodies	>2 publications with ZFPM2 and Fibrosis

Organs/Tissues associated with ZFPM2 cdna clone

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>32 publications with ZFPM2 and Heart
Testis Antibodies	>19 publications with ZFPM2 and Testis
Embryonic Tissue Antibodies	>17 publications with ZFPM2 and Embryonic Tissue
Muscle Antibodies	>15 publications with ZFPM2 and Muscle
Ovary Antibodies	>10 publications with ZFPM2 and Ovary
Vascular Antibodies	>7 publications with ZFPM2 and Vascular
Brain Antibodies	>7 publications with ZFPM2 and Brain
Lung Antibodies	>6 publications with ZFPM2 and Lung
Liver Antibodies	>3 publications with ZFPM2 and Liver
Skin Antibodies	>1 publications with ZFPM2 and Skin