D3R/DRD3 ELISA Kit for Chicken

DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Cellular Component: cell projection; membrane; integral to plasma membrane; endocytic vesicle; apical part of cell; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; dopamine D2 receptor-like receptor activity; protein domain specific binding; protein binding; signal transducer activity; dopamine receptor activity; dopamine binding; drug binding; D1 dopamine receptor binding

Biological Process: synaptic transmission, dopaminergic; regulation of lipid metabolic process; prepulse inhibition; musculoskeletal movement, spinal reflex action; response to morphine; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of dopamine secretion; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; renin-angiotensin regulation of blood volume; visual learning; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of sodium:hydrogen antiporter activity; dopamine receptor, adenylate cyclase activating pathway; positive regulation of cytokinesis; response to drug; positive regulation of dopamine receptor signaling pathway; negative regulation of protein secretion; negative regulation of protein kinase B signaling cascade; positive regulation of mitosis; regulation of cAMP metabolic process; response to amphetamine; negative regulation of adenylate cyclase activity; regulation of multicellular organism growth; response to cocaine; arachidonic acid secretion; regulation of circadian sleep/wake cycle, sleep; cellular calcium ion homeostasis; negative regulation of oligodendrocyte differentiation; regulation of locomotion; G-protein coupled receptor protein signaling pathway; acid secretion; response to ethanol; negative regulation of dopamine receptor signaling pathway; G-protein coupled receptor internalization; dopamine receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter