Catechol O-Methyltransferase (COMT) Human Recombinant Protein

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 2.1.1.6; Methyltransferase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: axon; cytosol; dendritic spine; integral to membrane; membrane; mitochondrion; plasma membrane; postsynaptic membrane

Molecular Function: catechol O-methyltransferase activity; magnesium ion binding; O-methyltransferase activity; protein binding

Biological Process: cellular response to phosphate starvation; developmental process; dopamine catabolic process; estrogen metabolic process; female pregnancy; learning; methylation; negative regulation of dopamine metabolic process; negative regulation of smooth muscle cell proliferation; neurotransmitter biosynthetic process; neurotransmitter catabolic process; positive regulation of homocysteine metabolic process; regulation of sensory perception of pain; reproductive process in a multicellular organism; response to drug; response to lipopolysaccharide; response to organic cyclic substance; response to pain; short-term memory; synaptic transmission; xenobiotic metabolic process

Disease: Panic Disorder 1; Schizophrenia