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Dysferlin (DYSF) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7254114

MBS7254114 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dysferlin, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dysferlin, ELISA Kit
Full Product Name
Human Dysferlin ELISA Kit
Product Gene Name
DYSF elisa kit
Species Reactivity
Human
Assay Type
Competitive ELISA
Samples
Serum, Plasma, Cell Culture Supernatants, Body Fluid and Tissue Homogenate
Detection Range
100-2500pg/mL
Sensitivity
1.0pg/mL
Molecular Weight
222,315 Da
OMIM
AF075575 mRNA
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of DYSF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DYSF. It may not necessarily be applicable to this product.

NCBI GI #
3600028
NCBI GeneID
8291
NCBI Accession #
AAC63519.1
UniProt Secondary Accession #
A0FK00; B1PZ70; B1PZ71; B1PZ72; B1PZ73; B1PZ74; B1PZ75; B1PZ76; B1PZ77; B1PZ78; B1PZ79
UniProt Related Accession #
O75923
NCBI Official Full Name
dysferlin
NCBI Official Synonym Full Names
dysferlin
NCBI Official Symbol
DYSF
NCBI Official Synonym Symbols
MMD1; FER1L1; LGMD2B
UniProt Protein Name
Dysferlin
UniProt Synonym Protein Names
Dystrophy-associated fer-1-like protein; Fer-1-like protein 1
Protein Family
Dysferlin
UniProt Gene Name
DYSF
UniProt Synonym Gene Names
FER1L1
NCBI Protein Information
dysferlin

NCBI Summary for DYSF

The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2008]
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UniProt Comments for DYSF

Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress ().

Research Articles on DYSF

1. Immunofluorescence demonstrated that the percentage of complex I- and complex IV-deficient fibres was higher in patients with DYSF mutations than in age-matched controls. No clonally expanded mtDNA deletions were detected using long-range PCR in any of the analysed muscle fibres. Complex I and complex IV deficiency is higher in patients than age matched controls but patients do not have rearrangements of the mtDNA.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DYSF elisa kit

 Reference Product  PubMed Publications
 CAPN3 elisa kit  >27 publications with DYSF and CAPN3
 CAV3 elisa kit  >15 publications with DYSF and CAV3
 ANO5 elisa kit  >6 publications with DYSF and ANO5
 SGCA elisa kit  >4 publications with DYSF and SGCA
 SGCB elisa kit  >4 publications with DYSF and SGCB
 TRIM72 elisa kit  >4 publications with DYSF and TRIM72
 ANXA2 elisa kit  >4 publications with DYSF and ANXA2
 ANXA6 elisa kit  >2 publications with DYSF and ANXA6
 MMD2 elisa kit  >1 publications with DYSF and MMD2

Pathways associated with DYSF elisa kit

 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram

Diseases associated with DYSF elisa kit

 Disease Name  Pubmed Publications
 Miyoshi myopathy Antibodies  >153 publications with DYSF and Miyoshi myopathy
 Atrophy Antibodies  >48 publications with DYSF and Atrophy
 Inflammation Antibodies  >46 publications with DYSF and Inflammation
 Disease Models, Animal Antibodies  >44 publications with DYSF and Disease Models, Animal
 Necrosis Antibodies  >22 publications with DYSF and Necrosis
 Heart Diseases Antibodies  >20 publications with DYSF and Heart Diseases
 Limb-girdle muscular dystrophy, type 2B Antibodies  >12 publications with DYSF and Limb-girdle muscular dystrophy, type 2B
 Fibrosis Antibodies  >11 publications with DYSF and Fibrosis
 Hypertrophy Antibodies  >10 publications with DYSF and Hypertrophy
 Edema Antibodies  >3 publications with DYSF and Edema

Organs/Tissues associated with DYSF elisa kit

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >424 publications with DYSF and Muscle
 Blood Antibodies  >75 publications with DYSF and Blood
 Heart Antibodies  >31 publications with DYSF and Heart
 Nerve Antibodies  >27 publications with DYSF and Nerve
 Brain Antibodies  >15 publications with DYSF and Brain
 Embryonic Tissue Antibodies  >8 publications with DYSF and Embryonic Tissue
 Vascular Antibodies  >8 publications with DYSF and Vascular
 Lung Antibodies  >7 publications with DYSF and Lung
 Placenta Antibodies  >7 publications with DYSF and Placenta
 Kidney Antibodies  >5 publications with DYSF and Kidney
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