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Fc Gamma RIIB/C (FCGR2B) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9139675

Description: Recombinant Human Fc gamma RIIB/C Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala46-Pro217) of human Fc gamma RIIB/C (Accession #NP_003992.3) fused with a 6xHis tag at the C-terminus.Background:… More details

$215 / 0.01 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Fc gamma RIIB/C (FCGR2B), Active Protein
Full Product Name
Recombinant Human Fc gamma RIIB/C Protein
Product Gene Name
FCGR2B active protein
Product Synonym Names
CD32; CD32B; FCG2; FCGR2; IGFR2
Sequence
APPKAVLKLE PQWINVLQED SVTLTCRGTH SPESDSIQWF HNGNLIPTHT QPSYRFKANN NDSGEYTCQT GQTSLSDPVH LTVLSEWLVL QTPHLEFQEG ETIVLRCHSW KDKPLVKVTF FQNGKSKKFS RSDPNFSIPQ ANHSHSGDYH CTGNIGYTLY SSKPVTITVQ AP
Host
HEK293 Cells
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Purity/Purification
>97% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
OMIM
152700
3D Structure
ModBase 3D Structure for P31994
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD32b at 10 ug/ml (100 ul/well) can bind human IgG2 with a linear range of 0.16-6.4 ug/ml.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
6xHis tag at the C-terminus

Product Categories/Family for FCGR2B active protein

Fc & Fc Receptor
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of FCGR2B active protein

Recombinant Human Fc gamma RIIB/C Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 25-35 kDa.
Human FCGR2B Active Protein – Cat# MBS9139675

Other Notes

Small volumes of FCGR2B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCGR2B purchase

MBS9139675 is an active protein targeting FCGR2B. Also known as Recombinant Human Fc gamma RIIB/C Protein. Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.

NCBI GI #
50511932
NCBI GeneID
2213
NCBI Accession #
NP_001002273.1
UniProt Primary Accession #
P31994
UniProt Related Accession #
P31994
GenBank Nucleotide #
NP_001002273.1
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor II-b isoform 2
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIb
NCBI Official Symbol
FCGR2B
NCBI Official Synonym Symbols
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-b
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR2B
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b
UniProt Entry Name
FCG2B_HUMAN
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-b

NCBI Summary for FCGR2B

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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UniProt Comments for FCGR2B

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Cell surface; Oncoprotein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; IgG binding

Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction

Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To
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Research Articles on FCGR2B

1. Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCGR2B active protein

 Reference Product  PubMed Publications
 CRP active protein  >5 publications with FCGR2B and CRP
 APCS active protein  >5 publications with FCGR2B and APCS
 LYN active protein  >2 publications with FCGR2B and LYN
 BLK active protein  >2 publications with FCGR2B and BLK
 PTPN6 active protein  >1 publications with FCGR2B and PTPN6
 MAPK1 active protein  >1 publications with FCGR2B and MAPK1

Pathways associated with FCGR2B active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with FCGR2B active protein

 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >113 publications with FCGR2B and Autoimmune Diseases
 Lupus Erythematosus, Systemic Antibodies  >62 publications with FCGR2B and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >45 publications with FCGR2B and Inflammation
 Kidney Diseases Antibodies  >22 publications with FCGR2B and Kidney Diseases
 Neoplasms Antibodies  >22 publications with FCGR2B and Neoplasms
 Nervous System Diseases Antibodies  >14 publications with FCGR2B and Nervous System Diseases
 Necrosis Antibodies  >13 publications with FCGR2B and Necrosis
 Brain Diseases Antibodies  >5 publications with FCGR2B and Brain Diseases
 Liver Diseases Antibodies  >3 publications with FCGR2B and Liver Diseases
 Malaria Antibodies  >3 publications with FCGR2B and Malaria

Organs/Tissues associated with FCGR2B active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >156 publications with FCGR2B and Blood
 Spleen Antibodies  >25 publications with FCGR2B and Spleen
 Bone Marrow Antibodies  >17 publications with FCGR2B and Bone Marrow
 Lymph Node Antibodies  >16 publications with FCGR2B and Lymph Node
 Kidney Antibodies  >14 publications with FCGR2B and Kidney
 Lung Antibodies  >8 publications with FCGR2B and Lung
 Brain Antibodies  >8 publications with FCGR2B and Brain
 Liver Antibodies  >5 publications with FCGR2B and Liver
 Connective Tissue Antibodies  >2 publications with FCGR2B and Connective Tissue
 Skin Antibodies  >2 publications with FCGR2B and Skin
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