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Fibroblast Growth Factor-20 (FGF20) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140879

Introduction: Fibroblast growth factor 20 (FGF20) belongs to the FGF gene family and member of FGF-9 subfamily (based upon its structure). Human FGF20 has several receptors which include FGF R1c, FGF R2c, FGF R3b, FGF R3c and FGF R4. FGF20 is expressed a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Fibroblast Growth Factor-20 (FGF20), Active Protein
Full Product Name
Recombinant Human Fibroblast Growth Factor-20
Product Gene Name
FGF20 active protein
Product Synonym Names
FGF20 Human; Fibroblast Growth Factor-20 Human Recombinant; Fibroblast Growth Factor 20; FGF-20; RHDA2; FGF20
Sequence
MHHHHHHAPL AEVGGFLGGL EGLGQQVGSH FLLPPAGERP PLLGERRSAA ERSARGGPGA AQLAHLHGIL RRRQLYCRTG FHLQILPDGS VQGTRQDHSL FGILEFISVA VGLVSIRGVD SGLYLGMNDK GELYGSEKLT SECIFREQFE ENWYNTYSSN IYKHGDTGRR YFVALNKDGT PRDGARSKRH QKFTHFLPRP VDPERVPELY KDLLMYT
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered solution in MOPS, (NH4)2SO4, DTT and EDTA.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 97.0% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized FGF20 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-20 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
23,499 Da
OMIM
605558
3D Structure
ModBase 3D Structure for Q9NP95
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50, as measured in a proliferation assay using mouse NR6R-3T3 cells, is less than 2.5ng/ml.
Solubility
It is recommended to reconstitute the lyophilized FGF-20 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for FGF20 active protein

Cytokines and Growth Factors

Other Notes

Small volumes of FGF20 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF20 purchase

MBS140879 is an active protein targeting FGF20. Also known as Recombinant Human Fibroblast Growth Factor-20. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF20. It may not necessarily be applicable to this product.

NCBI GI #
9789947
NCBI GeneID
26281
NCBI Accession #
NP_062825.1
UniProt Primary Accession #
Q9NP95
UniProt Secondary Accession #
B2RPH5
UniProt Related Accession #
Q9NP95
GenBank Nucleotide #
NM_019851.2
NCBI Official Full Name
fibroblast growth factor 20
NCBI Official Synonym Full Names
fibroblast growth factor 20
NCBI Official Symbol
FGF20
NCBI Official Synonym Symbols
RHDA2; FGF-20
UniProt Protein Name
Fibroblast growth factor 20
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF20
UniProt Synonym Gene Names
FGF-20
UniProt Entry Name
FGF20_HUMAN
NCBI Protein Information
fibroblast growth factor 20

UniProt Comments for FGF20

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: 1-phosphatidylinositol-3-kinase activity; growth factor activity; heparan sulfate proteoglycan binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of neuron apoptosis; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of dopamine secretion; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Renal Hypodysplasia/aplasia 2
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FGF20 active protein

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with FGF20 active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with FGF20 and Nervous System Diseases
 Carcinoma Antibodies  >7 publications with FGF20 and Carcinoma
 Inflammation Antibodies  >4 publications with FGF20 and Inflammation
 Ovarian Neoplasms Antibodies  >3 publications with FGF20 and Ovarian Neoplasms
 Liver Diseases Antibodies  >2 publications with FGF20 and Liver Diseases
 Necrosis Antibodies  >2 publications with FGF20 and Necrosis
 Gonadal Disorders Antibodies  >2 publications with FGF20 and Gonadal Disorders
 Tremor Antibodies  >2 publications with FGF20 and Tremor
 Sarcoma Antibodies  >1 publications with FGF20 and Sarcoma
 Depressive Disorder Antibodies  >1 publications with FGF20 and Depressive Disorder

Organs/Tissues associated with FGF20 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with FGF20 and Brain
 Intestine Antibodies  >6 publications with FGF20 and Intestine
 Lung Antibodies  >3 publications with FGF20 and Lung
 Eye Antibodies  >1 publications with FGF20 and Eye
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