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Sorbitol Dehydrogenase (SORD) Assay Kit for General

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8243258

Background/Introduction: Sorbitol dehydrogenase (SDH), found in organisms from bacteria to humans, converts sorbitol, the sugar alcohol form of glucose, to fructose, and the zinc-dependent reaction uses NAD+ as a cofactor. Organs abundant in SDH activity… More details

$460 / 100 Assays +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sorbitol Dehydrogenase (SORD), Assay Kit
Full Product Name
Sorbitol Dehydrogenase Microplate Assay Kit
Product Gene Name
SORD assay kit
Product Synonym Names
EC 1.1.1.14; Sorbitol dehydrogenase; SDH; SORD; L-iditol 2-dehydrogenase; Glucitol dehydrogenase; Polyol dehydrogenase; Sorbitol dehydrogenase
Species Reactivity
General
Samples
Urine, serum, plasma, tissue extracts, cell lysate, cell culture media and other biological fluids samples
Detection Range
4 umol/L - 400 umol/L
Preparation and Storage
Shipped and store at 4 degree C for 6 months.
Molecular Weight
10,812 Da
OMIM
182500
Applications Tested/Suitable for SORD assay kit
Functional Assay

Typical Testing Data/Standard Curve (for reference only) of SORD assay kit

General SORD Assay Kit – Cat# MBS8243258

Other Notes

Small volumes of SORD assay kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SORD purchase

MBS8243258 is an assay kit targeting SORD. Also known as Sorbitol Dehydrogenase Microplate Assay Kit. Reactive in General.

Additional Details

NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.

NCBI GI #
156627571
NCBI GeneID
6652
NCBI Accession #
NP_003095.2
UniProt Secondary Accession #
Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5
UniProt Related Accession #
Q00796
GenBank Nucleotide #
NM_003104.5
NCBI Official Full Name
sorbitol dehydrogenase
NCBI Official Synonym Full Names
sorbitol dehydrogenase
NCBI Official Symbol
SORD
NCBI Official Synonym Symbols
SORD1; HEL-S-95n
UniProt Protein Name
Sorbitol dehydrogenase
UniProt Synonym Protein Names
L-iditol 2-dehydrogenase
Protein Family
PTS system sorbose-specific EIID component
UniProt Gene Name
SORD
UniProt Entry Name
DHSO_HUMAN
NCBI Protein Information
sorbitol dehydrogenase

NCBI Summary for SORD

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
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UniProt Comments for SORD

SORD: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.14; Oxidoreductase

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: cytosol; extracellular space; membrane; mitochondrial membrane

Molecular Function: carbohydrate binding; D-xylulose reductase activity; identical protein binding; L-iditol 2-dehydrogenase activity; NAD binding; zinc ion binding

Biological Process: carbohydrate metabolic process; fructose biosynthetic process; fructose metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate; L-xylitol catabolic process; L-xylitol metabolic process; response to cadmium ion; response to copper ion; response to drug; response to hormone stimulus; response to nutrient levels; response to osmotic stress; sorbitol catabolic process; sperm motility
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Research Articles on SORD

1. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SORD assay kit

 Products by Pathway  Pathway Diagram
 Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway antibodies  Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose Biosynthesis Pathway antibodies  Fructose Biosynthesis Pathway Diagram
 Fructose Metabolism Pathway antibodies  Fructose Metabolism Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with SORD assay kit

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SORD and Liver Diseases
 Liver Cirrhosis Antibodies  >1 publications with SORD and Liver Cirrhosis
 Neoplasms, Experimental Antibodies  >1 publications with SORD and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with SORD and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >1 publications with SORD and Lung Neoplasms
 Liver Neoplasms Antibodies  >1 publications with SORD and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SORD and Kidney Diseases

Organs/Tissues associated with SORD assay kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with SORD and Blood
 Brain Antibodies  >8 publications with SORD and Brain
 Eye Antibodies  >4 publications with SORD and Eye
 Kidney Antibodies  >3 publications with SORD and Kidney
 Liver Antibodies  >3 publications with SORD and Liver
 Vascular Antibodies  >2 publications with SORD and Vascular
 Muscle Antibodies  >2 publications with SORD and Muscle
 Larynx Antibodies  >1 publications with SORD and Larynx
 Testis Antibodies  >1 publications with SORD and Testis
 Thyroid Antibodies  >1 publications with SORD and Thyroid
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