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BCMA Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691719

BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB… More details

$305 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCMA, Active Protein
Full Product Name
Human BCMA
Product Gene Name
Product Synonym Names
Recombinant Human BCMA
Sequence
AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVK GTNA
Host
E Coli
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
> 95% by SDS-PAGE and HPLC analyses
Molecular Weight
5.3 kDa
Chromosome Location
Chromosome: 16; NC_000016.10 (11965107..11968068). Location: 16p13.1
OMIM
109545
3D Structure
ModBase 3D Structure for Q02223
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng per ug of BCMA
Biological Activity
Data not available.

Product Categories/Family for BCMA active protein

ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of BCMA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCMA purchase

MBS691719 is an active protein targeting BCMA. Also known as Human BCMA. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCMA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 17
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Official Symbol
TNFRSF17
NCBI Official Synonym Symbols
BCM; BCMA; CD269; TNFRSF13A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein
UniProt Gene Name
TNFRSF17
UniProt Synonym Gene Names
BCM; BCMA
UniProt Entry Name
TNR17_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein

NCBI Summary for BCMA

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
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UniProt Comments for BCMA

Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. Ref.9 Ref.10 Ref.11

Subunit structure: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

Subcellular location: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note: Perinuclear Golgi-like structures.

Tissue specificity: Expressed in mature B-cells, but not in T-cells or monocytes.

Involvement in disease: A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Sequence similarities: Contains 1 TNFR-Cys repeat.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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