Human IFN-gamma Active Protein – Cat# MBS691547

IFN-gamma Human Active Protein

Name: IFN-gamma Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691547
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691547

Interferon-gamma (IFN-gamma) is a lymphoid factor which possesses potent anti-viral activity. It has also been shown to stimulate macrophages and NK cells. Recombinant Human IFN-gamma is a 16.7 kDa protein containing 143 amino acid residues. More details

$305 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFN-gamma, Active Protein

Full Product Name

Human IFN-gamma

Product Gene Name

IFN-gamma active protein

Product Synonym Names

Recombinant Human IFN-gamma

Sequence

MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIM QSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR D DFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLF QGR RASQ

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Molecular Weight

16.7 kDa

Chromosome Location

Chromosome: 12; NC_000012.12 (68154770..68159741, complement). Location: 12q14

OMIM

147570

3D Structure

ModBase 3D Structure for P01579

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per g of IFN-gamma

Biological Activity

Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml. Assay #2: The ED50 was determined by a cytotoxicity assay using HT-29 cells is <= 0.05 ng/ml (> 2 x 107 units/mg).

Product Categories/Family for IFN-gamma active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IFN-gamma active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFN-gamma purchase

MBS691547 is an active protein targeting IFN-gamma. Also known as Human IFN-gamma. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFN-gamma. It may not necessarily be applicable to this product.

NCBI GI #

56786138

NCBI GeneID

3458

NCBI Accession #

NP_000610.2

UniProt Primary Accession #

P01579

UniProt Secondary Accession #

Q53ZV4; B5BU88

UniProt Related Accession #

P01579

GenBank Nucleotide #

NM_000619.2

NCBI Official Full Name

interferon gamma

NCBI Official Synonym Full Names

interferon, gamma

NCBI Official Symbol

IFNG

NCBI Official Synonym Symbols

IFG; IFI

UniProt Protein Name

Interferon gamma

UniProt Synonym Protein Names

Immune interferon

Protein Family

Interferon gamma receptor

UniProt Gene Name

IFNG

UniProt Synonym Gene Names

IFN-gamma

UniProt Entry Name

IFNG_HUMAN

NCBI Protein Information

interferon gamma; IFN-gamma; immune interferon

NCBI Summary for IFN-gamma

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]

UniProt Comments for IFN-gamma

Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure: Homodimer.

Subcellular location: Secreted.

Tissue specificity: Released primarily from activated T lymphocytes.

Post-translational modification: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

Involvement in disease: Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Pharmaceutical use: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).

Sequence similarities: Belongs to the type II (or gamma) interferon family.

Research Articles on IFN-gamma

1. CXCR4 mRNA (p < 0.001) and CXCL12 mRNA (p = 0.02) relative expressions were significantly correlated with relative IFNgamma mRNA expression in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFN-gamma active protein

Reference Product	PubMed Publications
CD4 active protein	>125 publications with IFN-gamma and CD4
TBX21 active protein	>46 publications with IFN-gamma and TBX21
IL2 active protein	>45 publications with IFN-gamma and IL2
STAT1 active protein	>31 publications with IFN-gamma and STAT1
IFNGR1 active protein	>25 publications with IFN-gamma and IFNGR1
IL18 active protein	>21 publications with IFN-gamma and IL18
IRF1 active protein	>16 publications with IFN-gamma and IRF1
CD86 active protein	>3 publications with IFN-gamma and CD86

Pathways associated with IFN-gamma active protein

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram

Diseases associated with IFN-gamma active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>113 publications with IFN-gamma and Necrosis
Autoimmune Diseases Antibodies	>75 publications with IFN-gamma and Autoimmune Diseases
Respiratory Tract Diseases Antibodies	>56 publications with IFN-gamma and Respiratory Tract Diseases
Hepatitis Antibodies	>26 publications with IFN-gamma and Hepatitis
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies	>21 publications with IFN-gamma and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
Lymphoproliferative Disorders Antibodies	>17 publications with IFN-gamma and Lymphoproliferative Disorders
Diabetes Mellitus, Type 1 Antibodies	>15 publications with IFN-gamma and Diabetes Mellitus, Type 1
HIV Infections Antibodies	>13 publications with IFN-gamma and HIV Infections
Arthritis, Rheumatoid Antibodies	>12 publications with IFN-gamma and Arthritis, Rheumatoid
Hepatitis C Antibodies	>11 publications with IFN-gamma and Hepatitis C

Organs/Tissues associated with IFN-gamma active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>378 publications with IFN-gamma and Blood
Kidney Antibodies	>32 publications with IFN-gamma and Kidney
Lymph Node Antibodies	>22 publications with IFN-gamma and Lymph Node