Human IFN-lambda1 (IL-29) Active Protein – Cat# MBS691987

IFN-lambda1 (IL-29) Human Active Protein

Name: IFN-lambda1 (IL-29) Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691987
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691987

IFN lambda-1,-2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFN-lambda1 (IL-29), Active Protein

Full Product Name

Human IFN-lambda1 (IL-29)

Product Gene Name

IFN-lambda1 (IL-29) active protein

Product Synonym Names

Recombinant Human IFN lambda-1

Sequence

PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSC SSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED V LDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKK ESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analysis

Molecular Weight

19.8 kDa

Chromosome Location

Chromosome: 19; NC_000019.10 (39296325..39298672). Location: 19q13.13

OMIM

607403

3D Structure

ModBase 3D Structure for Q8IU54

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of IFN lambda-1

Biological Activity

Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.

Product Categories/Family for IFN-lambda1 (IL-29) active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IFN-lambda1 (IL-29) active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFN-lambda1 (IL-29) purchase

MBS691987 is an active protein targeting IFN-lambda1 (IL-29). Also known as Human IFN-lambda1 (IL-29). Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IFN-lambda1 (IL-29). It may not necessarily be applicable to this product.

NCBI GI #

26024325

NCBI GeneID

282618

NCBI Accession #

NP_742152.1

UniProt Primary Accession #

Q8IU54

UniProt Secondary Accession #

Q17R34; A0AV25

UniProt Related Accession #

Q8IU54

GenBank Nucleotide #

NM_172140.1

NCBI Official Full Name

interferon lambda-1

NCBI Official Synonym Full Names

interferon, lambda 1

NCBI Official Symbol

IFNL1

NCBI Official Synonym Symbols

IL29; IL-29

UniProt Protein Name

Interferon lambda-1

UniProt Synonym Protein Names

Cytokine Zcyto21; Interleukin-29

UniProt Gene Name

IFNL1

UniProt Synonym Gene Names

IL29; ZCYTO21; IFN-lambda-1; IL-29

UniProt Entry Name

IFNL1_HUMAN

NCBI Protein Information

interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)

NCBI Summary for IFN-lambda1 (IL-29)

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

UniProt Comments for IFN-lambda1 (IL-29)

Function: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Subcellular location: Secreted.

Induction: By viral infections or double-stranded RNA.

Sequence similarities: Belongs to the lambda interferon family.

Research Articles on IFN-lambda1 (IL-29)

1. IL-32 levels during viral infection mediate antiviral effects by stimulating the expression of IFN-lambda1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFN-lambda1 (IL-29) active protein

Reference Product	PubMed Publications
TLR3 active protein	>2 publications with IFN-lambda1 (IL-29) and TLR3

Pathways associated with IFN-lambda1 (IL-29) active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Type III Interferon Signaling Pathway antibodies	Type III Interferon Signaling Pathway Diagram