Human IL-13 Active Protein – Cat# MBS691889

IL-13 Human Active Protein

Name: IL-13 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS691889
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691889

Interleukin-13 is an immunoregulatory protein produced by activated T-lymphocytes. The biological activities of IL-13 include the stimulation of B cell proliferation and immunoglobulins production. Recombinant Human IL-13 is a 12.5 kDa protein containing 114… More details

$305 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-13, Active Protein

Full Product Name

Human IL-13

Product Gene Name

IL-13 active protein

Product Synonym Names

Recombinant Human IL-13

Sequence

MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMY CAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT K IEVAQFVKD LLLHLKKLFR EGRFN

Host

E Coli

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Molecular Weight

12.5 kDa

Chromosome Location

Chromosome: 5; NC_000005.10 (132658173..132661109). Location: 5q31

OMIM

147683

3D Structure

ModBase 3D Structure for P35225

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per g of IL-13

Biological Activity

The ED50 as determined by the dose-dependent proliferation of TF-1 cells was <= 1.0 ng/ml, corresponding to a specific activity of >= 1 x 106 units/mg.

Product Categories/Family for IL-13 active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of IL-13 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-13 purchase

MBS691889 is an active protein targeting IL-13. Also known as Human IL-13. Reactive in Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-13. It may not necessarily be applicable to this product.

NCBI GI #

26787978

NCBI GeneID

3596

NCBI Accession #

NP_002179.2

UniProt Primary Accession #

P35225

UniProt Secondary Accession #

O43644; Q4VB52; Q9UDC7

UniProt Related Accession #

P35225

GenBank Nucleotide #

NM_002188.2

NCBI Official Full Name

interleukin-13

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

IL13

NCBI Official Synonym Symbols

P600; IL-13

UniProt Protein Name

Interleukin-13

UniProt Gene Name

IL13

UniProt Synonym Gene Names

NC30; IL-13

UniProt Entry Name

IL13_HUMAN

NCBI Protein Information

interleukin-13

NCBI Summary for IL-13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

UniProt Comments for IL-13

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure: Interacts with IL13RA2.

Subcellular location: Secreted.

Involvement in disease: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Caution: It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on IL-13

1. IL-13 is synthesized and released by skeletal muscle through a mechanism involving let-7, and this effect is attenuated in skeletal muscle from insulin-resistant T2 Diabetes mellitus patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-13 active protein

Reference Product	PubMed Publications
STAT6 active protein	>390 publications with IL-13 and STAT6
IL13RA1 active protein	>290 publications with IL-13 and IL13RA1
IL5 active protein	>100 publications with IL-13 and IL5
GATA3 active protein	>91 publications with IL-13 and GATA3
IL18 active protein	>86 publications with IL-13 and IL18
IL4R active protein	>57 publications with IL-13 and IL4R
TSLP active protein	>29 publications with IL-13 and TSLP
IL13RA2 active protein	>12 publications with IL-13 and IL13RA2
VCAM1 active protein	>5 publications with IL-13 and VCAM1

Pathways associated with IL-13 active protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with IL-13 active protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>1301 publications with IL-13 and Hypersensitivity
Respiratory Tract Diseases Antibodies	>1265 publications with IL-13 and Respiratory Tract Diseases
Inflammation Antibodies	>1241 publications with IL-13 and Inflammation
Asthma Antibodies	>1203 publications with IL-13 and Asthma
Hypersensitivity, Immediate Antibodies	>1132 publications with IL-13 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>1104 publications with IL-13 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>940 publications with IL-13 and Respiratory Hypersensitivity
Necrosis Antibodies	>599 publications with IL-13 and Necrosis
Fibrosis Antibodies	>306 publications with IL-13 and Fibrosis
Bronchial Hyperreactivity Antibodies	>224 publications with IL-13 and Bronchial Hyperreactivity

Organs/Tissues associated with IL-13 active protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>172 publications with IL-13 and Brain
Bone Marrow Antibodies	>133 publications with IL-13 and Bone Marrow
Mixed Antibodies	>66 publications with IL-13 and Mixed
Testis Antibodies	>6 publications with IL-13 and Testis