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CD30 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801188

CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD30, Antibody
Full Product Name
Anti-Hu CD30 FITC
Product Gene Name
anti-CD30 antibody
Product Synonym Gene Name
TNFRSF8
Product Synonym Names
TNF receptor superfamily member 8; Ki-1; TNFRSF8; CD30L receptor; D1S166E
Isotype
IgG
Clone Number
MEM-268
Host
Mouse
Species Reactivity
Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Specificity
The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells; it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Matching Pairs
Unconjugated Antibody: CD30 Clone #MEM-268 (MBS1801186)
FITC Conjugated Antibody: CD30 Clone #MEM-268 (MBS1801188)
OMIM
153243
3D Structure
ModBase 3D Structure for P28908
Immunogen
Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
Conjugation
FITC
Applications Tested/Suitable for anti-CD30 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD30 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD30 antibody

Flow cytometry analysis (surface staining) of K562 and SP2 cell lines with anti-CD30 (MEM-268) FITC.
Mouse Anti-CD30 Antibody – Cat# MBS1801188

Other Notes

Small volumes of anti-CD30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD30 purchase

MBS1801188 is an antibody targeting CD30. Also known as Anti-Hu CD30 FITC. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD30. It may not necessarily be applicable to this product.

NCBI GI #
597709795
NCBI GeneID
943
NCBI Accession #
NP_001234.3
UniProt Primary Accession #
P28908
UniProt Related Accession #
P28908
GenBank Nucleotide #
NP_001234.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 8 isoform 1
NCBI Official Synonym Full Names
TNF receptor superfamily member 8
NCBI Official Symbol
TNFRSF8
NCBI Official Synonym Symbols
CD30; Ki-1; D1S166E
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 8
UniProt Synonym Protein Names
CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
Protein Family
CD302 antigen
UniProt Gene Name
TNFRSF8
UniProt Synonym Gene Names
CD30; D1S166E
UniProt Entry Name
TNR8_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 8

NCBI Summary for CD30

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD30

TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to lipopolysaccharide; signal transduction
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Research Articles on CD30

1. Hodgkin and Reed/Sternberg (HRS) cells shared typical transcriptome patterns with CD30+ B cells, suggesting that they originate from these lymphocytes or acquire their characteristic features during lymphomagenesis. By comparing HRS to normal CD30+ B cells we redefined aberrant and disease-specific features of HRS cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD30 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >415 publications with CD30 and CD4
 ALK antibody  >200 publications with CD30 and ALK
 CD5 antibody  >105 publications with CD30 and CD5
 TNFSF8 antibody  >97 publications with CD30 and TNFSF8
 TRAF2 antibody  >36 publications with CD30 and TRAF2
 TRAF1 antibody  >27 publications with CD30 and TRAF1
 ICAM1 antibody  >23 publications with CD30 and ICAM1
 TRAF3 antibody  >13 publications with CD30 and TRAF3
 TRAF5 antibody  >10 publications with CD30 and TRAF5
 FUT4 antibody  >6 publications with CD30 and FUT4

Pathways associated with anti-CD30 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-CD30 antibody

 Disease Name  Pubmed Publications
 Hodgkin Disease Antibodies  >600 publications with CD30 and Hodgkin Disease
 Necrosis Antibodies  >318 publications with CD30 and Necrosis
 Inflammation Antibodies  >96 publications with CD30 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >66 publications with CD30 and Cell Transformation, Neoplastic
 Fever Antibodies  >64 publications with CD30 and Fever
 Hyperplasia Antibodies  >59 publications with CD30 and Hyperplasia
 Neoplasm Metastasis Antibodies  >51 publications with CD30 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >47 publications with CD30 and Disease Models, Animal
 Liver Diseases Antibodies  >46 publications with CD30 and Liver Diseases
 Kidney Diseases Antibodies  >29 publications with CD30 and Kidney Diseases

Organs/Tissues associated with anti-CD30 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1210 publications with CD30 and Blood
 Lymph Node Antibodies  >360 publications with CD30 and Lymph Node
 Lung Antibodies  >79 publications with CD30 and Lung
 Intestine Antibodies  >28 publications with CD30 and Intestine
 Embryonic Tissue Antibodies  >24 publications with CD30 and Embryonic Tissue
 Testis Antibodies  >23 publications with CD30 and Testis
 Uterus Antibodies  >7 publications with CD30 and Uterus
 Salivary Gland Antibodies  >2 publications with CD30 and Salivary Gland
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