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CD71 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801113

CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by… More details

$295 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD71, Antibody
Full Product Name
Anti-Hu CD71 Purified
Product Gene Name
anti-CD71 antibody
Product Synonym Gene Name
TFRC
Product Synonym Names
transferrin receptor; Transferrin Receptor; TfR1; TfR; TR; Trfr; T9; p90; TFRC
Isotype
IgG1
Clone Number
MEM-189
Host
Mouse
Species Reactivity
Human
Form/Format
Tris buffered saline (TBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The antibody MEM-189 reacts with an extracellular epitope on CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-189 does not block binding of transferrin to the receptor.
Preparation and Storage
Store at 2-8 degree C.
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Immunogen
KG1 human acute myelogenous leukaemia cell line
Applications Tested/Suitable for anti-CD71 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD71 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD71 antibody

Separation of K562 cells stained using anti-human CD71 (MEM-189) purified antibody (concentration in sample 4 ug/ml, GAM APC, red) from K562 cells unstained by primary antibody (GAM APC, grey) in flow cytometry analysis (surface staining).
Mouse Anti-CD71 Antibody – Cat# MBS1801113

Other Notes

Small volumes of anti-CD71 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD71 purchase

MBS1801113 is an antibody targeting CD71. Also known as Anti-Hu CD71 Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD71. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Related Accession #
P02786
GenBank Nucleotide #
NP_001121620.1
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for CD71

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for CD71

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation
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Research Articles on CD71

1. TfR1 expression (and VEGF) expression was correlated to shorter overall survival in osteosarcoma patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD71 antibody

 Reference Product  PubMed Publications
 HFE antibody  >18 publications with CD71 and HFE
 CD4 antibody  >1 publications with CD71 and CD4

Pathways associated with anti-CD71 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with anti-CD71 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with CD71 and Neoplasms
 Iron Metabolism Disorders Antibodies  >28 publications with CD71 and Iron Metabolism Disorders
 Anemia Antibodies  >16 publications with CD71 and Anemia
 Disease Models, Animal Antibodies  >11 publications with CD71 and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >8 publications with CD71 and Anemia, Iron-Deficiency
 Lung Neoplasms Antibodies  >7 publications with CD71 and Lung Neoplasms
 Liver Diseases Antibodies  >6 publications with CD71 and Liver Diseases
 Brain Diseases Antibodies  >5 publications with CD71 and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with CD71 and Breast Neoplasms
 Drug Toxicity Antibodies  >4 publications with CD71 and Drug Toxicity

Organs/Tissues associated with anti-CD71 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with CD71 and Blood
 Liver Antibodies  >22 publications with CD71 and Liver
 Brain Antibodies  >16 publications with CD71 and Brain
 Intestine Antibodies  >11 publications with CD71 and Intestine
 Lung Antibodies  >10 publications with CD71 and Lung
 Bone Antibodies  >8 publications with CD71 and Bone
 Skin Antibodies  >7 publications with CD71 and Skin
 Kidney Antibodies  >7 publications with CD71 and Kidney
 Embryonic Tissue Antibodies  >6 publications with CD71 and Embryonic Tissue
 Prostate Antibodies  >5 publications with CD71 and Prostate
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