GCGR Antibody – Homo Sapiens

GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; endosome

Molecular Function: peptide hormone binding; guanyl-nucleotide exchange factor activity; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity

Disease: Diabetes Mellitus, Noninsulin-dependent