Mouse Anti-KI67 Antibody – Cat# MBS850631

Figure 1. Immunohistochemical analysis of paraffin-embedded human lymph node (A), esophagus (B), lung cancer (C), rectum cancer (D), showing nuclear localization using KI67 mouse mAb with DAB staining.

KI67 Antibody – Mouse

Name: KI67 Antibody; Mouse; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS850631
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850631

Ki67, also known as MKI67, it is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing… More details

$380 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KI67, Antibody

Full Product Name

KI67 Antibody

Product Gene Name

anti-KI67 antibody

Product Synonym Names

KIA; Ki-67; MKI67

Isotype

IgG2b

Clone Number

4A1

Host

Mouse

Species Reactivity

Human

Form/Format

Ascitic fluid containing 0.03% sodium azide.

Preparation and Storage

Store at 4 degree C, for long term storage, store at-20 degree C

Molecular Weight

358kDa

OMIM

176741

3D Structure

ModBase 3D Structure for P46013

Immunogen

Synthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human KI67, conjugated to KLH.

Product Categories/Family for anti-KI67 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-KI67 antibody

Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-KI67 antibody

IHC: 1:200-1:1000
ELISA: 1:10000

Other Notes

Small volumes of anti-KI67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KI67 purchase

MBS850631 is an antibody targeting KI67. Also known as KI67 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KI67. It may not necessarily be applicable to this product.

NCBI GI #

225543215

NCBI GeneID

4288

NCBI Accession #

NP_001139438.1

UniProt Primary Accession #

P46013

UniProt Secondary Accession #

Q5VWH2

UniProt Related Accession #

P46013

GenBank Nucleotide #

NM_001145966.1

NCBI Official Full Name

proliferation marker protein Ki-67 isoform 2

NCBI Official Synonym Full Names

marker of proliferation Ki-67

NCBI Official Symbol

MKI67

NCBI Official Synonym Symbols

KIA; MIB-; MIB-1; PPP1R105

UniProt Protein Name

Proliferation marker protein Ki-67

UniProt Synonym Protein Names

Antigen identified by monoclonal antibody Ki-67

Protein Family

Proliferation marker protein

UniProt Gene Name

MKI67

UniProt Synonym Gene Names

Antigen KI-67Curated; Antigen Ki67Curated

NCBI Protein Information

proliferation marker protein Ki-67

NCBI Summary for KI67

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

UniProt Comments for KI67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Research Articles on KI67

1. High Ki-67 expression in localized PCa is a factor of poor prognosis for prostate cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KI67 antibody

Reference Product	PubMed Publications
MKI67IP antibody	>8 publications with KI67 and MKI67IP
CBX3 antibody	>1 publications with KI67 and CBX3

Diseases associated with anti-KI67 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>9254 publications with KI67 and Neoplasms
Adenocarcinoma Antibodies	>2117 publications with KI67 and Adenocarcinoma
Breast Neoplasms Antibodies	>1548 publications with KI67 and Breast Neoplasms
Nervous System Diseases Antibodies	>1433 publications with KI67 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>1044 publications with KI67 and Neoplasm Metastasis
Carcinoma, Squamous Cell Antibodies	>981 publications with KI67 and Carcinoma, Squamous Cell
Adenoma Antibodies	>693 publications with KI67 and Adenoma
Hyperplasia Antibodies	>583 publications with KI67 and Hyperplasia
Colorectal Neoplasms Antibodies	>581 publications with KI67 and Colorectal Neoplasms
Neoplasms, Experimental Antibodies	>534 publications with KI67 and Neoplasms, Experimental

Organs/Tissues associated with anti-KI67 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1742 publications with KI67 and Blood
Brain Antibodies	>1239 publications with KI67 and Brain
Vascular Antibodies	>1110 publications with KI67 and Vascular
Lymph Node Antibodies	>1097 publications with KI67 and Lymph Node
Lymph Antibodies	>1092 publications with KI67 and Lymph
Skin Antibodies	>869 publications with KI67 and Skin
Lung Antibodies	>635 publications with KI67 and Lung
Liver Antibodies	>604 publications with KI67 and Liver
Muscle Antibodies	>596 publications with KI67 and Muscle
Bone Antibodies	>523 publications with KI67 and Bone