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LYAR Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8514620

MBS8514620 is an antibody targeting LYAR. Also known as LYAR Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LYAR, Antibody
Full Product Name
LYAR Antibody
Product Gene Name
anti-LYAR antibody
Product Synonym Names
likely ortholog of mouse Ly1 antibody reactive clone
Species Reactivity
Human
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Immunogen affinity purified
Specificity
LYAR Antibody detects endogenous levels of total LYAR
Preparation and Storage
Store at-20 degree C. Stable for 12 months from date of receipt.
Molecular Weight
44 KD
OMIM
617684
3D Structure
ModBase 3D Structure for Q9NX58
Immunogen
A synthesized peptide
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LYAR antibody
Western Blot (WB)
Application Notes for anti-LYAR antibody
WB: 1:500-1:1000

Western Blot (WB) of anti-LYAR antibody

Western blot analysis of extracts from LOVO cells, HepG2 cells and Jurkat cells, using LYAR antibody
Anti-LYAR Antibody – Cat# MBS8514620

Other Notes

Small volumes of anti-LYAR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LYAR. It may not necessarily be applicable to this product.

NCBI GI #
224591430
NCBI GeneID
55646
NCBI Accession #
NP_001139197.1
UniProt Primary Accession #
Q9NX58
UniProt Secondary Accession #
Q6FI78; Q9NYS1; D3DVS4
UniProt Related Accession #
Q9NX58
GenBank Nucleotide #
NM_001145725.1
NCBI Official Full Name
cell growth-regulating nucleolar protein
NCBI Official Synonym Full Names
Ly1 antibody reactive
NCBI Official Symbol
LYAR
NCBI Official Synonym Symbols
ZLYAR; ZC2HC2
UniProt Protein Name
Cell growth-regulating nucleolar protein
Protein Family
Cell growth-regulating nucleolar protein
UniProt Gene Name
LYAR
NCBI Protein Information
cell growth-regulating nucleolar protein

UniProt Comments for LYAR

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal ().
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Research Articles on LYAR

1. Data suggest that LYAR induces proliferation and promotes survival of neuroblastoma cells by repressing the expression of oxidative stress genes such as CHAC1 and suppressing oxidative stress, and identify LYAR as a novel co-factor in N-Myc oncogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-LYAR antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >3 publications with LYAR and Lymphoma
 Neoplasms Antibodies  >2 publications with LYAR and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with LYAR and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with LYAR and Lung Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with LYAR and Congenital Abnormalities
 Nervous System Diseases Antibodies  >1 publications with LYAR and Nervous System Diseases
 Nervous System Malformations Antibodies  >1 publications with LYAR and Nervous System Malformations
 Kidney Neoplasms Antibodies  >1 publications with LYAR and Kidney Neoplasms
 Liver Neoplasms Antibodies  >1 publications with LYAR and Liver Neoplasms

Organs/Tissues associated with anti-LYAR antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >2 publications with LYAR and Testis
 Lung Antibodies  >1 publications with LYAR and Lung
 Bone Antibodies  >1 publications with LYAR and Bone
 Blood Antibodies  >1 publications with LYAR and Blood
 Heart Antibodies  >1 publications with LYAR and Heart
 Kidney Antibodies  >1 publications with LYAR and Kidney
 Liver Antibodies  >1 publications with LYAR and Liver
 Brain Antibodies  >1 publications with LYAR and Brain
 Bone Marrow Antibodies  >1 publications with LYAR and Bone Marrow
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