Rabbit Anti-MKI67 Antibody – Cat# MBS8504599

Western blot analysis of extracts of HeLacell lines, using MKI67 antibody.

MKI67 Antibody – Rabbit

Name: MKI67 Antibody; Rabbit; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8504599
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8504599

Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2,… More details

$400 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MKI67, Antibody

Full Product Name

MKI67 Antibody

Product Gene Name

anti-MKI67 antibody

Product Synonym Names

MKI67; KIA; Antigen KI-67; Ki-67

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Affinity purification

Preparation and Storage

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

Molecular Weight

359kDa

OMIM

176741

3D Structure

ModBase 3D Structure for P46013

Immunogen

Recombinant protein of human MKI67

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-MKI67 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-MKI67 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-MKI67 antibody

WB: 1:500-1:2000
IHC: 1:50-1:200

Product References and Citations for anti-MKI67 antibody

1. Gerdes, J. et al. (1983) Int J Cancer 31, 13-20. 2. Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62. 3. Jones, R.L. et al. (2009) Breast Cancer Res Treat 116, 53-68. 4. Yerushalmi, R. et al. (2010) Lancet Oncol 11, 174-83.

Other Notes

Small volumes of anti-MKI67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MKI67 purchase

MBS8504599 is an antibody targeting MKI67. Also known as MKI67 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MKI67. It may not necessarily be applicable to this product.

NCBI GI #

225543215

NCBI GeneID

4288

NCBI Accession #

NP_001139438.1

UniProt Primary Accession #

P46013

UniProt Secondary Accession #

Q5VWH2

UniProt Related Accession #

P46013

GenBank Nucleotide #

NM_001145966.1

NCBI Official Full Name

proliferation marker protein Ki-67 isoform 2

NCBI Official Synonym Full Names

marker of proliferation Ki-67

NCBI Official Symbol

MKI67

NCBI Official Synonym Symbols

KIA; MIB-; MIB-1; PPP1R105

UniProt Protein Name

Proliferation marker protein Ki-67

UniProt Synonym Protein Names

Antigen identified by monoclonal antibody Ki-67

Protein Family

Proliferation marker protein

UniProt Gene Name

MKI67

UniProt Synonym Gene Names

Antigen KI-67Curated; Antigen Ki67Curated

NCBI Protein Information

proliferation marker protein Ki-67

NCBI Summary for MKI67

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

UniProt Comments for MKI67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Research Articles on MKI67

1. High Ki-67 expression in localized PCa is a factor of poor prognosis for prostate cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MKI67 antibody

Reference Product	PubMed Publications
MKI67IP antibody	>8 publications with MKI67 and MKI67IP
CBX3 antibody	>1 publications with MKI67 and CBX3

Diseases associated with anti-MKI67 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>9254 publications with MKI67 and Neoplasms
Adenocarcinoma Antibodies	>2117 publications with MKI67 and Adenocarcinoma
Breast Neoplasms Antibodies	>1548 publications with MKI67 and Breast Neoplasms
Nervous System Diseases Antibodies	>1433 publications with MKI67 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>1044 publications with MKI67 and Neoplasm Metastasis
Carcinoma, Squamous Cell Antibodies	>981 publications with MKI67 and Carcinoma, Squamous Cell
Adenoma Antibodies	>693 publications with MKI67 and Adenoma
Hyperplasia Antibodies	>583 publications with MKI67 and Hyperplasia
Colorectal Neoplasms Antibodies	>581 publications with MKI67 and Colorectal Neoplasms
Neoplasms, Experimental Antibodies	>534 publications with MKI67 and Neoplasms, Experimental

Organs/Tissues associated with anti-MKI67 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1742 publications with MKI67 and Blood
Brain Antibodies	>1239 publications with MKI67 and Brain
Vascular Antibodies	>1110 publications with MKI67 and Vascular
Lymph Node Antibodies	>1097 publications with MKI67 and Lymph Node
Lymph Antibodies	>1092 publications with MKI67 and Lymph
Skin Antibodies	>869 publications with MKI67 and Skin
Lung Antibodies	>635 publications with MKI67 and Lung
Liver Antibodies	>604 publications with MKI67 and Liver
Muscle Antibodies	>596 publications with MKI67 and Muscle
Bone Antibodies	>523 publications with MKI67 and Bone