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PDHA1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8526885

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. More details

$295 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDHA1, Antibody
Full Product Name
PDHA1 Antibody
Product Gene Name
anti-PDHA1 antibody
Product Synonym Names
Mouse monoclonal IgG to PDHA1
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Protein G-Sepharose affinity purified
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
47,580 Da
OMIM
300502
3D Structure
ModBase 3D Structure for P08559
Immunogen
Recombinant fragment of human PDHA1 (C-terminus).
Preservative
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Cellular Localization
Mitochondrion
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PDHA1 antibody
ELSIA (EIA), Western Blot (WB)
Application Notes for anti-PDHA1 antibody
ELISA: 1:5000-1:20000
WB: 1:100-1:2000

Testing Data of anti-PDHA1 antibody

PDHA1 (C-terminus) antibody at 1/1000 dilution. Lane1: A549 whole cell lysate 40ug/Lane. Lane2: Hela whole cell lysate 40ug/Lane. Predicted band size: 43KDa. Observed band size: 50KDa.
Anti-PDHA1 Antibody – Cat# MBS8526885

Other Notes

Small volumes of anti-PDHA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDHA1 purchase

MBS8526885 is an antibody targeting PDHA1. Also known as PDHA1 Antibody. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for PDHA1. It may not necessarily be applicable to this product.

NCBI GI #
4505685
NCBI GeneID
5160
NCBI Accession #
NP_000275.1
UniProt Primary Accession #
P08559
UniProt Secondary Accession #
Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5; A5YVE9; B2R5P7; B7Z3T7; B7Z3X5
UniProt Related Accession #
P08559
GenBank Nucleotide #
NM_000284.3
NCBI Official Full Name
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1
NCBI Official Synonym Full Names
pyruvate dehydrogenase E1 alpha 1 subunit
NCBI Official Symbol
PDHA1
NCBI Official Synonym Symbols
PDHA; PDHAD; PHE1A; PDHCE1A
UniProt Protein Name
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
UniProt Synonym Protein Names
PDHE1-A type I
Protein Family
Pyruvate dehydrogenase E1 component
UniProt Gene Name
PDHA1
UniProt Synonym Gene Names
PHE1A
NCBI Protein Information
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

NCBI Summary for PDHA1

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
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UniProt Comments for PDHA1

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.

Research Articles on PDHA1

1. Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDHA1 antibody

 Reference Product  PubMed Publications
 PDHB antibody  >7 publications with PDHA1 and PDHB
 DLAT antibody  >2 publications with PDHA1 and DLAT
 PDP1 antibody  >1 publications with PDHA1 and PDP1

Pathways associated with anti-PDHA1 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Synthesis Pathway antibodies  Acetylcholine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis And Gluconeogenesis Pathway antibodies  Glycolysis And Gluconeogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-PDHA1 antibody

 Disease Name  Pubmed Publications
 Pyruvate Metabolism, Inborn Errors Antibodies  >32 publications with PDHA1 and Pyruvate Metabolism, Inborn Errors
 Pyruvate Dehydrogenase Complex Deficiency Disease Antibodies  >32 publications with PDHA1 and Pyruvate Dehydrogenase Complex Deficiency Disease
 Neurobehavioral Manifestations Antibodies  >32 publications with PDHA1 and Neurobehavioral Manifestations
 Acidosis, Lactic Antibodies  >18 publications with PDHA1 and Acidosis, Lactic
 Leigh Syndrome, X-Linked Antibodies  >4 publications with PDHA1 and Leigh Syndrome, X-Linked
 Muscular Diseases Antibodies  >2 publications with PDHA1 and Muscular Diseases
 Nervous System Malformations Antibodies  >2 publications with PDHA1 and Nervous System Malformations
 Cardiomyopathies Antibodies  >1 publications with PDHA1 and Cardiomyopathies
 Cardiovascular Diseases Antibodies  >1 publications with PDHA1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with PDHA1 and Kidney Diseases

Organs/Tissues associated with anti-PDHA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with PDHA1 and Brain
 Muscle Antibodies  >9 publications with PDHA1 and Muscle
 Skin Antibodies  >6 publications with PDHA1 and Skin
 Blood Antibodies  >5 publications with PDHA1 and Blood
 Testis Antibodies  >4 publications with PDHA1 and Testis
 Connective Tissue Antibodies  >1 publications with PDHA1 and Connective Tissue
 Eye Antibodies  >1 publications with PDHA1 and Eye
 Liver Antibodies  >1 publications with PDHA1 and Liver
 Embryonic Tissue Antibodies  >1 publications with PDHA1 and Embryonic Tissue
 Adipose Tissue Antibodies  >1 publications with PDHA1 and Adipose Tissue
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