PKC-epsilon Antibody

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.

Protein type: EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; AGC group; PKC family; Eta subfamily

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: actin monomer binding; protein serine/threonine kinase activity; calcium-independent protein kinase C activity; signal transducer activity; protein binding; enzyme binding; protein kinase C activity; metal ion binding; enzyme activator activity; ethanol binding; ATP binding; receptor activator activity

Biological Process: positive regulation of cytokinesis; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of synaptic transmission, GABAergic; response to morphine; positive regulation of insulin secretion; positive regulation of lipid catabolic process; signal transduction; cell cycle; protein amino acid phosphorylation; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of MAPKKK cascade; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; innate immune response; cell adhesion; blood coagulation; regulation of peptidyl-tyrosine phosphorylation