• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ROR1 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850362

ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are… More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ROR1, Antibody
Full Product Name
ROR1 Antibody
Product Gene Name
anti-ROR1 antibody
Product Synonym Names
ROR1
Isotype
IgG1
Clone Number
2H6
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Molecular Weight
101kDa
OMIM
602336
3D Structure
ModBase 3D Structure for Q01973
Immunogen
Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

Product Categories/Family for anti-ROR1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ROR1 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-ROR1 antibody
WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:10000

Immunofluorescence (IF) of anti-ROR1 antibody

Figure 1. Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue. DRAQ5 fluorescent DNA dye.
Mouse Anti-ROR1 Antibody – Cat# MBS850362

Western Blot (WB) of anti-ROR1 antibody

Figure 2. Western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).
Mouse Anti-ROR1 Antibody, Western Blot (WB) – Cat# MBS850362

Other Notes

Small volumes of anti-ROR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ROR1 purchase

MBS850362 is an antibody targeting ROR1. Also known as ROR1 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ROR1. It may not necessarily be applicable to this product.

NCBI GI #
134152686
NCBI GeneID
4919
NCBI Accession #
NP_001077061.1
UniProt Primary Accession #
Q01973
UniProt Secondary Accession #
Q5VVX6; Q66K77; Q92776
UniProt Related Accession #
Q01973
GenBank Nucleotide #
NM_001083592.1
NCBI Official Full Name
inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2
NCBI Official Synonym Full Names
receptor tyrosine kinase like orphan receptor 1
NCBI Official Symbol
ROR1
NCBI Official Synonym Symbols
NTRKR1; dJ537F10.1
UniProt Protein Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1
UniProt Synonym Protein Names
Neurotrophic tyrosine kinase, receptor-related 1
Protein Family
Inactive tyrosine-protein kinase transmembrane receptor
UniProt Gene Name
ROR1
UniProt Synonym Gene Names
NTRKR1
NCBI Protein Information
inactive tyrosine-protein kinase transmembrane receptor ROR1

NCBI Summary for ROR1

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Show more

UniProt Comments for ROR1

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
Show more

Research Articles on ROR1

1. ROR1 is a promising immunotherapeutic target in many epithelial tumors; however, high cell surface ROR1 expression in multiple normal tissues raises concerns for on-target off-tumor toxicities. Clinical translation of ROR1-targeted therapies warrants careful monitoring of toxicities to normal organs and may require strategies to ensure patient safety
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ROR1 antibody

 Reference Product  PubMed Publications
 WNT5A antibody  >29 publications with ROR1 and WNT5A
 STAT3 antibody  >5 publications with ROR1 and STAT3
 VANGL2 antibody  >3 publications with ROR1 and VANGL2
 WNT3 antibody  >3 publications with ROR1 and WNT3

Pathways associated with anti-ROR1 antibody

 Products by Pathway  Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 PCP/CE Pathway antibodies  PCP/CE Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway antibodies  WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway Netpath antibodies  Wnt Signaling Pathway Netpath Diagram

Diseases associated with anti-ROR1 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >9 publications with ROR1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with ROR1 and Breast Neoplasms
 Lung Diseases Antibodies  >6 publications with ROR1 and Lung Diseases
 Disease Models, Animal Antibodies  >5 publications with ROR1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >5 publications with ROR1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >3 publications with ROR1 and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with ROR1 and Liver Diseases
 Inflammation Antibodies  >3 publications with ROR1 and Inflammation
 Necrosis Antibodies  >3 publications with ROR1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with ROR1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-ROR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with ROR1 and Blood
 Brain Antibodies  >21 publications with ROR1 and Brain
 Lung Antibodies  >20 publications with ROR1 and Lung
 Embryonic Tissue Antibodies  >16 publications with ROR1 and Embryonic Tissue
 Bone Antibodies  >15 publications with ROR1 and Bone
 Stomach Antibodies  >7 publications with ROR1 and Stomach
 Heart Antibodies  >6 publications with ROR1 and Heart
 Lymph Node Antibodies  >5 publications with ROR1 and Lymph Node
 Thyroid Antibodies  >4 publications with ROR1 and Thyroid
 Vascular Antibodies  >4 publications with ROR1 and Vascular
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000