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SLC7A7 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423770

MBS423770 is an antibody targeting SLC7A7. Also known as Goat anti-SLC7A7/y+LAT-1 Antibody. Reactive in Human. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SLC7A7/y+LAT-1, Antibody
Full Product Name
Goat anti-SLC7A7/y+LAT-1 Antibody
Product Gene Name
anti-SLC7A7 antibody
Product Synonym Names
SLC7A7; solute carrier family 7 (amino acid transporter light chain, y+L system), member 7; LAT3; LPI; MOP-2; Y+LAT1; y+LAT-1; Y+L amino acid transporter 1; monocyte amino acid permease 2; solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; y(+)L-type amino acid transporter 1
Species Reactivity
Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
SLC7A7 peptide (MBS428802) is used for blocking the activity of SLC7A7/y+LAT-1 antibody (MBS423770)
Molecular Weight
56.0kDa
OMIM
222700
3D Structure
ModBase 3D Structure for Q9UM01
Immunogen Sequence
Peptide with sequence SQPEVETSPLGD-C, from the N Terminus of the protein sequence according to NP_001119577.1.
Peptide Sequence + C
SQPEVETSPLGD-C
Epitope
N Terminus
Note
Reported variants represent identical protein: NP_001119577.1, NP_001119578.1
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SLC7A7 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-SLC7A7 antibody
Pep-ELISA: antibody detection limit dilution 1:128000.
WB: Approx 55-58kDa band observed in Human Lung and Skeletal Muscle lysates. Recommended concentration: 1-3ug/ml.

Immunohistochemistry (IHC) of anti-SLC7A7 antibody

(2ug/ml) staining of Human Lung (A) and Skeletal Muscle (B) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
Anti-SLC7A7 Antibody – Cat# MBS423770

Other Notes

Small volumes of anti-SLC7A7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC7A7. It may not necessarily be applicable to this product.

NCBI GI #
186910306
NCBI GeneID
9056
NCBI Accession #
NP_001119577.1
UniProt Primary Accession #
Q9UM01
UniProt Secondary Accession #
O95984; Q53XC1; Q86U07; Q9P2V5; B2RAU0; D3DS26
UniProt Related Accession #
Q9UM01
GenBank Nucleotide #
NM_001126105.2
NCBI Official Full Name
Y+L amino acid transporter 1
NCBI Official Synonym Full Names
solute carrier family 7 member 7
NCBI Official Symbol
SLC7A7
NCBI Official Synonym Symbols
LPI; LAT3; MOP-2; Y+LAT1; y+LAT-1
UniProt Protein Name
Y+L amino acid transporter 1
UniProt Synonym Protein Names
Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1
Protein Family
Y+L amino acid transporter
UniProt Gene Name
SLC7A7
UniProt Synonym Gene Names
MOP-2; Y+LAT1; y+LAT-1
NCBI Protein Information
Y+L amino acid transporter 1

NCBI Summary for SLC7A7

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
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UniProt Comments for SLC7A7

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
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Research Articles on SLC7A7

1. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC7A7 antibody

 Reference Product  PubMed Publications
 SLC3A2 antibody  >8 publications with SLC7A7 and SLC3A2

Pathways associated with anti-SLC7A7 antibody

 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC7A7 antibody

 Disease Name  Pubmed Publications
 Lysinuric Protein Intolerance Antibodies  >59 publications with SLC7A7 and Lysinuric Protein Intolerance
 Amino Acid Metabolism, Inborn Errors Antibodies  >42 publications with SLC7A7 and Amino Acid Metabolism, Inborn Errors
 Kidney Diseases Antibodies  >14 publications with SLC7A7 and Kidney Diseases
 Lung Diseases Antibodies  >9 publications with SLC7A7 and Lung Diseases
 Inflammation Antibodies  >7 publications with SLC7A7 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with SLC7A7 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >3 publications with SLC7A7 and Lung Neoplasms
 Fibrosis Antibodies  >3 publications with SLC7A7 and Fibrosis
 Vascular Diseases Antibodies  >3 publications with SLC7A7 and Vascular Diseases
 Anemia Antibodies  >3 publications with SLC7A7 and Anemia

Organs/Tissues associated with anti-SLC7A7 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >27 publications with SLC7A7 and Intestine
 Blood Antibodies  >24 publications with SLC7A7 and Blood
 Kidney Antibodies  >23 publications with SLC7A7 and Kidney
 Brain Antibodies  >16 publications with SLC7A7 and Brain
 Lung Antibodies  >14 publications with SLC7A7 and Lung
 Embryonic Tissue Antibodies  >7 publications with SLC7A7 and Embryonic Tissue
 Vascular Antibodies  >7 publications with SLC7A7 and Vascular
 Bone Antibodies  >6 publications with SLC7A7 and Bone
 Placenta Antibodies  >6 publications with SLC7A7 and Placenta
 Uterus Antibodies  >3 publications with SLC7A7 and Uterus
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