ABRAXAS1 Peptide - C-Terminal Region Blocking Peptide

Name: ABRAXAS1 Peptide - C-Terminal Region Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3241629
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3241629

This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance,… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ABRAXAS1, Blocking Peptide

Full Product Name

ABRAXAS1 Peptide - C-terminal region

Product Gene Name

ABRAXAS1 blocking peptide

Product Synonym Gene Name

ABRA1; CCDC98; FAM175A; ABRAXAS1

Sequence

DDRWQFKRSR LLDTQDKRSK ADTGSSNQDK ASKMSSPETD EEIEKMKGFG

Species Reactivity

Human

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

ABRAXAS1 peptide (MBS3241629) is used for blocking the activity of ABRAXAS1 antibody (MBS3216729)

Molecular Weight

47kDa

OMIM

phenotype 611143

Product Categories/Family for ABRAXAS1 blocking peptide

Peptide

Applications Tested/Suitable for ABRAXAS1 blocking peptide

Western Blot (WB)

Other Notes

Small volumes of ABRAXAS1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABRAXAS1 purchase

MBS3241629 is a blocking peptide targeting ABRAXAS1. Also known as ABRAXAS1 Peptide - C-terminal region. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for ABRAXAS1. It may not necessarily be applicable to this product.

NCBI GI #

109148531

NCBI GeneID

84142

NCBI Accession #

NP_620775

UniProt Primary Accession #

Q6UWZ7

UniProt Related Accession #

Q6UWZ7

GenBank Nucleotide #

NM_139076

NCBI Official Full Name

BRCA1-A complex subunit Abraxas 1 isoform 1

NCBI Official Synonym Full Names

abraxas 1, BRCA1 A complex subunit

NCBI Official Symbol

ABRAXAS1

NCBI Official Synonym Symbols

ABRA1; CCDC98; FAM175A

UniProt Protein Name

BRCA1-A complex subunit Abraxas

UniProt Synonym Protein Names

Coiled-coil domain-containing protein 98; Protein FAM175A

UniProt Gene Name

FAM175A

UniProt Synonym Gene Names

ABRA1; CCDC98

UniProt Entry Name

F175A_HUMAN

NCBI Protein Information

BRCA1-A complex subunit Abraxas 1

UniProt Comments for ABRAXAS1

Abraxas: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Belongs to the FAM175 family. Abraxas subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: nucleus

Molecular Function: protein binding; polyubiquitin binding

Biological Process: positive regulation of DNA repair; double-strand break repair; chromatin modification; response to ionizing radiation; G2/M transition DNA damage checkpoint

Research Articles on ABRAXAS1

1. Our data also suggest how ataxia telangiectasia mutated (ATM)-dependent BRCA1 dimerization may stabilize self-association of the entire BRCA1-A complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ABRAXAS1 blocking peptide

Reference Product	PubMed Publications
BRCA1 blocking peptide	>23 publications with ABRAXAS1 and BRCA1
BRCC3 blocking peptide	>6 publications with ABRAXAS1 and BRCC3
BRE blocking peptide	>4 publications with ABRAXAS1 and BRE
BARD1 blocking peptide	>3 publications with ABRAXAS1 and BARD1
ATM blocking peptide	>2 publications with ABRAXAS1 and ATM
MRE11A blocking peptide	>2 publications with ABRAXAS1 and MRE11A
RAD50 blocking peptide	>1 publications with ABRAXAS1 and RAD50
UIMC1 blocking peptide	>1 publications with ABRAXAS1 and UIMC1

Diseases associated with ABRAXAS1 blocking peptide

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>7 publications with ABRAXAS1 and Breast Neoplasms
Ovarian Neoplasms Antibodies	>5 publications with ABRAXAS1 and Ovarian Neoplasms

Organs/Tissues associated with ABRAXAS1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with ABRAXAS1 and Lung