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DPH5 Peptide - Middle Region Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3246742

This is a synthetic peptide designed for use in combination with anti- DPH5 Antibody, madeTarget Description: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on… More details

$195 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DPH5, Blocking Peptide
Full Product Name
DPH5 Peptide - middle region
Product Gene Name
Product Synonym Gene Name
AD-018; CGI-30; NPD015; HSPC143
Sequence
Synthetic peptide located within the following region: QLYKFGETVS IVFWTDTWRP ESFFDKVKKN RQNGMHTLCL LDIKVKEQSL
Species Reactivity
Human
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Antibody/Peptide Pairs
DPH5 peptide (MBS3246742) is used for blocking the activity of DPH5 antibody (MBS3222028)
Molecular Weight
25 kDa
OMIM
611075

Product Categories/Family for DPH5 blocking peptide

Other Notes

Small volumes of DPH5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPH5 purchase

MBS3246742 is a blocking peptide targeting DPH5. Also known as DPH5 Peptide - middle region. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for DPH5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
diphthine methyl ester synthase isoform a
NCBI Official Synonym Full Names
diphthamide biosynthesis 5
NCBI Official Symbol
DPH5
NCBI Official Synonym Symbols
AD-018; CGI-30; NPD015; HSPC143
UniProt Protein Name
Diphthine synthase
UniProt Synonym Protein Names
Diphthamide biosynthesis methyltransferase
UniProt Gene Name
DPH5
UniProt Entry Name
DPH5_HUMAN
NCBI Protein Information
diphthine methyl ester synthase

NCBI Summary for DPH5

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for DPH5

DPH5: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. Belongs to the diphthine synthase family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.98

Chromosomal Location of Human Ortholog: 1p21.2

Cellular Component: cytosol

Molecular Function: diphthine synthase activity

Biological Process: methylation; cellular protein metabolic process; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; post-translational protein modification
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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