EPHX2 Immunizing Blocking Peptide

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

EPHX2: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.

Protein type: EC 3.1.3.76; Lipid Metabolism - arachidonic acid; Hydrolase; EC 3.3.2.10

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; cytosol; peroxisome

Molecular Function: epoxide hydrolase activity; lipid phosphatase activity; lipid-phosphate phosphatase activity; magnesium ion binding; phosphoric monoester hydrolase activity; protein homodimerization activity; receptor binding; toxin binding

Biological Process: cellular calcium ion homeostasis; cholesterol homeostasis; dephosphorylation; drug metabolic process; epoxygenase P450 pathway; inflammatory response; phospholipid dephosphorylation; positive regulation of vasodilation; regulation of blood pressure; response to toxin; stilbene catabolic process; xenobiotic metabolic process

Disease: Hypercholesterolemia, Familial