F11R Peptide - C-Terminal Region Blocking Peptide

Name: F11R Peptide - C-Terminal Region Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3246321
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3246321

This is a synthetic peptide designed for use in combination with anti- F11R Antibody, madeTarget Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

F11R, Blocking Peptide

Full Product Name

F11R Peptide - C-terminal region

Product Gene Name

F11R blocking peptide

Product Synonym Gene Name

JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1

Sequence

Synthetic peptide located within the following region: GVIVAAVLVT LILLGILVFG IWFAYSRGHF DRTKKGTSSK KVIYSQPSAR

Species Reactivity

Human

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

F11R peptide (MBS3246321) is used for blocking the activity of F11R antibody (MBS3221588)

Molecular Weight

32 kDa

OMIM

605721

Product Categories/Family for F11R blocking peptide

Peptide

Other Notes

Small volumes of F11R blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for F11R purchase

MBS3246321 is a blocking peptide targeting F11R. Also known as F11R Peptide - C-terminal region. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for F11R. It may not necessarily be applicable to this product.

NCBI GI #

8393638

NCBI GeneID

50848

NCBI Accession #

NP_058642.1

UniProt Primary Accession #

Q9Y624

UniProt Related Accession #

Q9Y624

GenBank Nucleotide #

NM_016946.4

NCBI Official Full Name

junctional adhesion molecule A isoform 1

NCBI Official Synonym Full Names

F11 receptor

NCBI Official Symbol

F11R

NCBI Official Synonym Symbols

JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1

UniProt Protein Name

Junctional adhesion molecule A

UniProt Synonym Protein Names

Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1

Protein Family

Junctional adhesion molecule

UniProt Gene Name

F11R

UniProt Synonym Gene Names

JAM1; JCAM; JAM-A; JAM-1; PAM-1

UniProt Entry Name

JAM1_HUMAN

NCBI Protein Information

junctional adhesion molecule A

NCBI Summary for F11R

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

UniProt Comments for F11R

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: microtubule cytoskeleton; tight junction; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; cell junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: intercellular junction assembly and maintenance; response to radiation; extracellular matrix organization and biogenesis; viral reproduction; transforming growth factor beta receptor signaling pathway; actomyosin structure organization and biogenesis; inflammatory response; cell adhesion; blood coagulation; leukocyte migration; positive regulation of blood pressure; intestinal absorption

Research Articles on F11R

1. These results demonstrate that therapeutic targeting of JAM-A has the potential to prevent MM progression, and lead us to propose JAM-A as a biomarker in MM, and sJAM-A as a serum-based marker for clinical stratification.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with F11R blocking peptide

Reference Product	PubMed Publications
TJP1 blocking peptide	>24 publications with F11R and TJP1
CLDN1 blocking peptide	>6 publications with F11R and CLDN1
MLLT4 blocking peptide	>2 publications with F11R and MLLT4
PARD6A blocking peptide	>1 publications with F11R and PARD6A
MPDZ blocking peptide	>1 publications with F11R and MPDZ

Pathways associated with F11R blocking peptide

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies	Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies	Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with F11R blocking peptide

Disease Name	Pubmed Publications
Inflammation Antibodies	>27 publications with F11R and Inflammation
Neoplasms Antibodies	>23 publications with F11R and Neoplasms
Necrosis Antibodies	>13 publications with F11R and Necrosis
Atherosclerosis Antibodies	>11 publications with F11R and Atherosclerosis
Disease Models, Animal Antibodies	>11 publications with F11R and Disease Models, Animal
Breast Neoplasms Antibodies	>11 publications with F11R and Breast Neoplasms
Neoplasm Metastasis Antibodies	>7 publications with F11R and Neoplasm Metastasis
Heart Diseases Antibodies	>6 publications with F11R and Heart Diseases
Brain Diseases Antibodies	>5 publications with F11R and Brain Diseases
Neoplasm Invasiveness Antibodies	>5 publications with F11R and Neoplasm Invasiveness

Organs/Tissues associated with F11R blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>66 publications with F11R and Blood
Vascular Antibodies	>47 publications with F11R and Vascular
Intestine Antibodies	>16 publications with F11R and Intestine
Heart Antibodies	>14 publications with F11R and Heart
Brain Antibodies	>13 publications with F11R and Brain
Lung Antibodies	>12 publications with F11R and Lung
Liver Antibodies	>12 publications with F11R and Liver
Kidney Antibodies	>9 publications with F11R and Kidney
Embryonic Tissue Antibodies	>8 publications with F11R and Embryonic Tissue
Eye Antibodies	>7 publications with F11R and Eye