TBL1X Peptide - Middle Region Blocking Peptide

TBL1X: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; histone binding; beta-catenin binding; transcription factor binding; transcription corepressor activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; sensory perception of sound; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; proteolysis