TRIM6 Immunizing Blocking Peptide

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

TRIM6: is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ligase activity; protein binding; protein binding, bridging; protein kinase binding; transcription factor binding; zinc ion binding

Biological Process: negative regulation of transcription, DNA-dependent; negative regulation of viral genome replication; positive regulation of cytokine secretion during immune response; positive regulation of defense response to virus by host; positive regulation of peptidyl-serine phosphorylation; protein polyubiquitination; response to lipopolysaccharide