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Gelsolin (GS) CLIA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2025432
SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment

The microplate provided in this kit has been pre-coated with an antibody specific to Gelsolin (GS). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Gelsolin (GS). Next, Avidin conjugated to… More details

$485 / 24-Strip-Wells +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gelsolin (GS), CLIA Kit
Full Product Name
Human Gelsolin (GS) CLIA Kit
Product Gene Name
GS clia kit
Product Synonym Names
GSN; AGEL; ADF; Brevin; Gelsolin Amyloidosis,Finnish Type; Actin-depolymerizing factor
Species Reactivity
Human
Assay Type
Double-antibody Sandwich
Samples
Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and other biological fluids
Detection Range
13.7-10,000pg/mL
Sensitivity
6.1pg/mL
Specificity
This assay has high sensitivity and excellent specificity for detection of Gelsolin (GS).
No significant cross-reactivity or interference between Gelsolin (GS) and analogues was observed.
Preparation and Storage
The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Molecular Weight
80,929 Da
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Application
Chemiluminescent immunoassay for Antigen Detection.
Intra-assay Precision (Precision within an assay)
3 samples with low, middle and high level Gelsolin (GS) were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays)
3 samples with low, middle and high level Gelsolin (GS) were tested on 3 different plates, 8 replicates in each plate.
CV(%) =
SD/meanX100
Intra-Assay
CV<10%
Inter-Assay
CV<12%

Product Categories/Family for GS clia kit

Tumor immunity; Infection immunity
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of GS clia kit

Human GS CLIA Kit – Cat# MBS2025432

Other Notes

Small volumes of GS clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GS purchase

MBS2025432 is a CLIA kit targeting GS. Also known as Human Gelsolin (GS) CLIA Kit. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for GS. It may not necessarily be applicable to this product.

NCBI GI #
51854227
NCBI GeneID
296654
NCBI Accession #
NP_001004080.1
UniProt Related Accession #
Q68FP1
GenBank Nucleotide #
NM_001004080.1
NCBI Official Full Name
gelsolin
NCBI Official Synonym Full Names
gelsolin
NCBI Official Symbol
Gsn
UniProt Protein Name
Gelsolin
UniProt Synonym Protein Names
Actin-depolymerizing factor; ADF; Brevin
UniProt Gene Name
Gsn
UniProt Synonym Gene Names
ADF
UniProt Entry Name
GELS_RAT
NCBI Protein Information
gelsolin

NCBI Summary for GS

plays a role in phosphoinositide mediated disassembly of actin filaments in Sertoli cell adhesion complexes; may regulate sperm release and turnover of the blood-testis barrier [RGD, Feb 2006]

UniProt Comments for GS

Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.

Protein type: Secreted; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Secreted, signal peptide; Actin-binding

Cellular Component: ruffle; extracellular space; protein complex; focal adhesion; perinuclear region of cytoplasm; lamellipodium; extracellular region; cytosol; actin cytoskeleton

Molecular Function: calcium ion binding; actin binding

Biological Process: regulation of cell adhesion; actin filament severing; phosphoinositide-mediated signaling; wound healing; apoptosis; actin nucleation; vesicle-mediated transport; response to ethanol; tissue regeneration; actin filament polymerization; response to folic acid; actin polymerization and/or depolymerization; oligodendrocyte development; barbed-end actin filament capping; aging
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Research Articles on GS

1. It was concluded that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-IIdelta, binding of CaMK-IIdelta and gelsolin to actin filaments, and cleavage of gelsolin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GS clia kit

 Reference Product  PubMed Publications
 Casp3 clia kit  >7 publications with GS and Casp3
 Ttr clia kit  >1 publications with GS and Ttr

Pathways associated with GS clia kit

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with GS clia kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with GS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >13 publications with GS and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >8 publications with GS and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >8 publications with GS and Carcinoma, Hepatocellular
 Inflammation Antibodies  >7 publications with GS and Inflammation
 Liver Diseases Antibodies  >6 publications with GS and Liver Diseases
 Liver Neoplasms Antibodies  >6 publications with GS and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with GS and Neoplasms, Experimental
 Heart Diseases Antibodies  >5 publications with GS and Heart Diseases
 Breast Neoplasms Antibodies  >4 publications with GS and Breast Neoplasms

Organs/Tissues associated with GS clia kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with GS and Brain
 Nerve Antibodies  >31 publications with GS and Nerve
 Liver Antibodies  >11 publications with GS and Liver
 Heart Antibodies  >11 publications with GS and Heart
 Lung Antibodies  >8 publications with GS and Lung
 Artery Antibodies  >7 publications with GS and Artery
 Kidney Antibodies  >5 publications with GS and Kidney
 Embryonic Tissue Antibodies  >3 publications with GS and Embryonic Tissue
 Adipose Tissue Antibodies  >3 publications with GS and Adipose Tissue
 Testis Antibodies  >2 publications with GS and Testis
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