Beta-NGF ELISA Kit for Human

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytoplasmic vesicle; endosome; extracellular region; Golgi lumen

Molecular Function: growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding

Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of MAPKK activity; cell-cell signaling; induction of apoptosis via death domain receptors; microtubule-based movement; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neuron projection morphogenesis; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of Ras protein signal transduction; regulation of caspase activity; regulation of neuron differentiation; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V