Il-13 ELISA Kit for Human

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; external side of plasma membrane; extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-13 receptor binding; protein binding

Biological Process: cell motility; cell-cell signaling; immune response; inflammatory response; microglial cell activation; negative regulation of NAD(P)H oxidase activity; positive regulation of B cell proliferation; positive regulation of connective tissue growth factor production; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation; positive regulation of protein secretion; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of proton transport; response to ethanol; response to lipopolysaccharide; response to nicotine; signal transduction

Disease: Allergic Rhinitis; Asthma, Susceptibility To