PNPLA8 Blocking Peptide – Cat# MBS8225468

PNPLA8 Blocking Peptide – >85% Purity

Name: PNPLA8 Blocking Peptide; >85% Purity; MyBioSource
Brand: MyBioSource
SKU: MBS8225468
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8225468

MBS8225468 is a blocking peptide targeting PNPLA8. Reactive in Human, Rat, Monkey, Rabbit. Host: Synthetic. The peptide is used to block Anti-PNPLA8 Antibody reactivity. More details

$230 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PNPLA8, Blocking Peptide

Full Product Name

PNPLA8 Blocking Peptide

Product Gene Name

PNPLA8 blocking peptide

Product Synonym Names

IPLA22; IPLA2G; Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2

Host

Synthetic

Species Reactivity

Human, Rat, Monkey, Rabbit

Form/Format

Lyophilized powder

Purity/Purification

>85%

Preparation and Storage

Shipped at 4 degree C. Store at -20 degree C for one year.

Antibody/Peptide Pairs

PNPLA8 peptide (MBS8225468) is used for blocking the activity of PNPLA8 antibody (MBS8239999)

Molecular Weight

77,031 Da

OMIM

612123

Quality Control

The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.

Directions for Use

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

Applications Tested/Suitable for PNPLA8 blocking peptide

Blocking (BL)

Other Notes

Small volumes of PNPLA8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PNPLA8. It may not necessarily be applicable to this product.

NCBI GI #

365192573

NCBI GeneID

50640

NCBI Accession #

NP_001242936.1

UniProt Primary Accession #

Q9NP80

UniProt Secondary Accession #

O95035; Q8N3I3; Q9H7T5; Q9NR17; Q9NUN2; Q9NZ79; A4D0S1; C9JZI4

UniProt Related Accession #

Q9NP80

GenBank Nucleotide #

NM_001256007.2

NCBI Official Full Name

calcium-independent phospholipase A2-gamma isoform 1

NCBI Official Synonym Full Names

patatin-like phospholipase domain containing 8

NCBI Official Symbol

PNPLA8

NCBI Official Synonym Symbols

MMLA; IPLA2G; IPLA2-2; iPLA2gamma; PNPLA-gamma

UniProt Protein Name

Calcium-independent phospholipase A2-gamma

UniProt Synonym Protein Names

Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2

Protein Family

Calcium-independent phospholipase

UniProt Gene Name

PNPLA8

UniProt Synonym Gene Names

IPLA22; IPLA2G; iPLA2-gamma

UniProt Entry Name

PLPL8_HUMAN

NCBI Protein Information

calcium-independent phospholipase A2-gamma

NCBI Summary for PNPLA8

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]

UniProt Comments for PNPLA8

PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Phospholipase; Membrane protein, integral; EC 3.1.1.5

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: Golgi membrane; peroxisomal membrane; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; integral to membrane; peroxisome; intracellular

Molecular Function: calcium-independent phospholipase A2 activity; ATP binding; lysophospholipase activity

Biological Process: cell death; phosphatidylethanolamine catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; linoleic acid metabolic process; arachidonic acid metabolic process; fatty acid metabolic process; arachidonic acid secretion; prostaglandin biosynthetic process

Disease: Mitochondrial Myopathy With Lactic Acidosis

Research Articles on PNPLA8

1. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PNPLA8 blocking peptide

Reference Product	PubMed Publications
CTTNBP2 blocking peptide	>1 publications with PNPLA8 and CTTNBP2

Pathways associated with PNPLA8 blocking peptide

Products by Pathway	Pathway Diagram
Acyl Chain Remodelling Of PC Pathway antibodies	Acyl Chain Remodelling Of PC Pathway Diagram
Acyl Chain Remodelling Of PE Pathway antibodies	Acyl Chain Remodelling Of PE Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
Glycerophospholipid Biosynthesis Pathway antibodies	Glycerophospholipid Biosynthesis Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Phospholipid Metabolism Pathway antibodies	Phospholipid Metabolism Pathway Diagram
Phospholipases Pathway antibodies	Phospholipases Pathway Diagram

Diseases associated with PNPLA8 blocking peptide

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with PNPLA8 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>1 publications with PNPLA8 and Nervous System Diseases
Seizures Antibodies	>1 publications with PNPLA8 and Seizures
Weight Loss Antibodies	>1 publications with PNPLA8 and Weight Loss

Organs/Tissues associated with PNPLA8 blocking peptide

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1 publications with PNPLA8 and Bone
Muscle Antibodies	>1 publications with PNPLA8 and Muscle
Heart Antibodies	>1 publications with PNPLA8 and Heart