MRPL40 Blocking Peptide – >85% Purity

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]

MRPL40:

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrion; nucleolus; nucleus

Molecular Function: protein binding

Biological Process: anatomical structure morphogenesis; mitochondrial translation; organelle organization and biogenesis