FASN Antibody – Rabbit

Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FASN is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FASN is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).Recently, increased expression of FASN has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FASN are directly related to the size of breast tumors (2). Studies also showed that FASN is highly expressed in lung and prostate cancers and that FASN expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FASN is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FASN as a potential target for the identification and treatment of cancer as well as metabolic syndrome (6, 7).

1. Katsurada, A. et al. (1990) Eur J Biochem 190, 427-33. 2. Wells, W.A. et al. (2006) Breast Cancer Res Treat 98, 231-40. 3. Kawamura, T. et al. (2005) Pathobiology 72, 233-240. 4. Shah, U.S. et al. (2006) Hum Pathol 37, 401-409. 5. Kuhajda, F.P. (2000) Nutrition 16, 202-8. 6. Tian, W.X. (2006) Curr Med Chem 13, 967-977. 7. Kusunoki, J. et al. (2006) Endocrine 29, 91-100.

Small volumes of anti-FASN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8500690 is an antibody targeting FASN. Also known as FASN Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.