Western blot analysis of GluR1 phosphorylation expression in PMA treated HeLa whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

GluR1 Antibody

Name: GluR1 Antibody; MyBioSource
Brand: MyBioSource
SKU: MBS8511487
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8511487

GluR1 an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. More details

$295 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GluR1, Antibody

Full Product Name

Phospho-GluR1 (Ser863) Antibody

Product Gene Name

anti-GluR1 antibody

Product Synonym Names

AMPA 1; AMPA-selective glutamate receptor 1; GLUH1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA; Glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GRIA1; HBGR1; MGC133252

Species Reactivity

Human, Mouse, Rat

Form/Format

In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Immunogen affinity purified

Specificity

Phospho-GluR1 (Ser863) Antibody detects endogenous levels of GluR1 only when phosphorylated at Serine 863

Preparation and Storage

Store at-20 degree C for 1 year

Molecular Weight

102kDa

OMIM

138248

3D Structure

ModBase 3D Structure for P42261

Immunogen

A synthesized peptide derived from human GluR1 around the phosphorylation site of Serine 863

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-GluR1 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-GluR1 antibody

WB: 1:500-1:2000
IHC: 1:50-1:200

Other Notes

Small volumes of anti-GluR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GluR1 purchase

MBS8511487 is an antibody targeting GluR1. Also known as Phospho-GluR1 (Ser863) Antibody. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for GluR1. It may not necessarily be applicable to this product.

NCBI GI #

167001419

NCBI GeneID

2890

NCBI Accession #

NP_000818.2

UniProt Primary Accession #

P42261

UniProt Secondary Accession #

Q2NKM6; B7Z2S0; B7Z2W8; B7Z3F6; B7Z9G9; D3DQI4; E7ESV8

UniProt Related Accession #

P42261

GenBank Nucleotide #

NM_000827.3

NCBI Official Full Name

glutamate receptor 1 isoform 1

NCBI Official Synonym Full Names

glutamate ionotropic receptor AMPA type subunit 1

NCBI Official Symbol

GRIA1

NCBI Official Synonym Symbols

GLUH1; GLUR1; GLURA; GluA1; HBGR1

UniProt Protein Name

Glutamate receptor 1

UniProt Synonym Protein Names

AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1

UniProt Gene Name

GRIA1

UniProt Synonym Gene Names

GLUH1; GLUR1; GluR-1; GluA1

NCBI Protein Information

glutamate receptor 1

NCBI Summary for GluR1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GluR1

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Research Articles on GluR1

1. The reversible binding of kynurenic acid (KYNA) on human glutamate receptor (GluR1) polypeptide (GluR1270-300)-modified gold surface has been studied at various temperatures under physiological conditions by two-dimensional SPR experiments. The registered sensorgrams were fitted by using different kinetic models without application of any commercial software. Results suggested that the binding reaction was exothermic.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GluR1 antibody

Reference Product	PubMed Publications
GRIA4 antibody	>8 publications with GluR1 and GRIA4
GRIK2 antibody	>6 publications with GluR1 and GRIK2
GRID2 antibody	>1 publications with GluR1 and GRID2

Pathways associated with anti-GluR1 antibody

Products by Pathway	Pathway Diagram
Activation Of AMPA Receptors Pathway antibodies	Activation Of AMPA Receptors Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Dopaminergic Synapse Pathway antibodies	Dopaminergic Synapse Pathway Diagram

Diseases associated with anti-GluR1 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>17 publications with GluR1 and Mental Disorders
Nervous System Diseases Antibodies	>4 publications with GluR1 and Nervous System Diseases
Brain Diseases Antibodies	>2 publications with GluR1 and Brain Diseases
Neurobehavioral Manifestations Antibodies	>2 publications with GluR1 and Neurobehavioral Manifestations
Anxiety Disorders Antibodies	>2 publications with GluR1 and Anxiety Disorders
Sexual Dysfunctions, Psychological Antibodies	>2 publications with GluR1 and Sexual Dysfunctions, Psychological
Neoplasms Antibodies	>1 publications with GluR1 and Neoplasms
Drug Toxicity Antibodies	>1 publications with GluR1 and Drug Toxicity
Substance-Related Disorders Antibodies	>1 publications with GluR1 and Substance-Related Disorders
Memory Disorders Antibodies	>1 publications with GluR1 and Memory Disorders