MEF2A ELISA Kit for Human, Mouse, Rat

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: activating transcription factor binding; chromatin binding; DNA binding transcription factor activity; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; SMAD binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Biological Process: apoptosis; cellular response to calcium ion; dendrite morphogenesis; ERK5 cascade; heart development; MAPK cascade; mitochondrial genome maintenance; mitochondrion distribution; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle hypertrophy; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril assembly

Disease: Coronary Artery Disease, Autosomal Dominant, 1