CD257 Human Protein

Information: The human B cell activating factor (BAFF,TALL-1, Blys, THANK) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily (TNFSFL #13b and 13 respectively). They are expressed by non-B cells, and are down regulated by mitogenic stimulation(2). BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells(3,4). Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells(1). Recently a third receptor for BAFF (BAFF-R) was described(5). BAFF and BAFFR knockout mice have a reduced numbers of mature B cells in the periphery, however TACI and BCMA knockouts do not share this phenotype, suggesting that BAFF-R may the primary receptor for BAFF in mice(8,9,10). Cell surface BAFF can be proteolytically cleaved to form a soluble trimeric molecule(2). Levels of soluble BAFF correspond with levels of autoantibodies in Sjogren's Syndrome(11). Recombinant BAFF(trn)-muCD8 binds to human cell surface TACI/BCMA/BAFFR.

1) Schneider P., J. Tschopp, et al. J. Exp. Med. 1999, 189(11):1747-1756. 2) Shu, H.B., H. Johnson, W.H. Hui. J Leukoc Biol 1999, 65:680-683. 3) Marsters, S.A., A. Ashkenazi, et al. 2000, Curr Biol 10:785-788. 4) Xia, X., H. Hsu, et al. 2000, J Exp Med, 192(1): 137-143. 5) Thompson J.S., C. Ambrose, et al. Science 2001, 293: 2108-2111. 6) Roschke, V, T.S. Migone, et al. J Immunol. 2002, 169: 4314-4321. 7) MacLennan, C.M., C.G. Vinuesa, 2002, Immunity 17:235-238. 8) B. Schiemann, et al, (2001) Science 293: 2111-2114. 9) S.M. Harless,et al, (2001) Curr Biol 11: 1988-1989. 10) Mol Cell Biol (2001) 21: 4067-4074. 11) X. Mariette, et al, (2003) Ann Rhem Dis 62: 168-171.

Small volumes of CD257 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS666876 is a protein targeting CD257. Also known as CD257(BAFF)(trn)-muCD8-Purified Preservative Free. Reactive in Human. Host: CHO cells.