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BCAN Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8248593

Recombinant Human BCAN Protein is produced by our mammalian expression system and the target gene encoding Asp23-Pro911 is expressed with a 6His tag at the C-terminus. More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCAN, Recombinant Protein
Full Product Name
Recombinant Human BCAN Protein
Product Gene Name
BCAN recombinant protein
Product Synonym Names
BEHAB; CSPG7; Brevican core protein; Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Sequence
DVLEGDSSED RAFRVRIAGD APLQGVLGGA LTIPCHVHYL RPPPSRRAVL GSPRVKWTFL SRGREAEVLV ARGVRVKVNE AYRFRVALPA YPASLTDVSL ALSELRPNDS GIYRCEVQHG IDDSSDAVEV KVKGVVFLYR EGSARYAFSF SGAQEACARI GAHIATPEQL YAAYLGGYEQ CDAGWLSDQT VRYPIQTPRE ACYGDMDGFP GVRNYGVVDP DDLYDVYCYA EDLNGELFLG DPPEKLTLEE ARAYCQERGA EIATTGQLYA AWDGGLDHCS PGWLADGSVR YPIVTPSQRC GGGLPGVKTL FLFPNQTGFP NKHSRFNVYC FRDSAQPSAI PEASNPASNP ASDGLEAIVT VTETLEELQL PQEATESESR GAIYSIPIME DGGGGSSTPE DPAEAPRTLL EFETQSMVPP TGFSEEEGKA LEEEEKYEDE EEKEEEEEEE EVEDEALWAW PSELSSPGPE ASLPTEPAAQ EKSLSQAPAR AVLQPGASPL PDGESEASRP PRVHGPPTET LPTPRERNLA SPSPSTLVEA REVGEATGGP ELSGVPRGES EETGSSEGAP SLLPATRAPE GTRELEAPSE DNSGRTAPAG TSVQAQPVLP TDSASRGGVA VVPASGDCVP SPCHNGGTCL EEEEGVRCLC LPGYGGDLCD VGLRFCNPGW DAFQGACYKH FSTRRSWEEA ETQCRMYGAH LASISTPEEQ DFINNRYREY QWIGLNDRTI EGDFLWSDGV PLLYENWNPG QPDSYFLSGE NCVVMVWHDQ GQWSDVPCNY HLSYTCKMGL VSCGPPPELP LAQVFGRPRL RYEVDTVLRY RCREGLAQRN LPLIRCQENG RWEAPQISCV PRRPARALHP EEDPEGRQGR LLGRWKALLI PPSSPMPGPH HHHHH
Host
Human cells
Species Reactivity
Human
Form/Format
Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Purity/Purification
Greater than 95% as determined by reducing SDS-PAGE.
Preparation and Storage
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
Molecular Weight
71,671 Da
OMIM
AF228710 mRNA
3D Structure
ModBase 3D Structure for Q96GW7
Endotoxin
Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
Directions for Use
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Applications Tested/Suitable for BCAN recombinant protein
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

Other Notes

Small volumes of BCAN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAN purchase

MBS8248593 is a recombinant protein targeting BCAN. Also known as Recombinant Human BCAN Protein. Reactive in Human. Host: Human cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAN. It may not necessarily be applicable to this product.

NCBI GI #
38372935
NCBI GeneID
63827
NCBI Accession #
NP_068767.3
UniProt Primary Accession #
Q96GW7
UniProt Secondary Accession #
Q5SZ10; Q5T3I5; Q8TBB9; Q9HBK1; Q9HBK4; D3DVC2
UniProt Related Accession #
Q96GW7
GenBank Nucleotide #
NM_021948.4
NCBI Official Full Name
brevican core protein isoform 1
NCBI Official Synonym Full Names
brevican
NCBI Official Symbol
BCAN
NCBI Official Synonym Symbols
BEHAB; CSPG7
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Protein Family
Brevican core protein
UniProt Gene Name
BCAN
UniProt Synonym Gene Names
BEHAB; CSPG7; BEHAB
UniProt Entry Name
PGCB_HUMAN
NCBI Protein Information
brevican core protein

NCBI Summary for BCAN

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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UniProt Comments for BCAN

BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: extracellular region; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding

Biological Process: cell adhesion; central nervous system development; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; skeletal development
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Research Articles on BCAN

1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCAN recombinant protein

 Reference Product  PubMed Publications
 ADAMTS4 recombinant protein  >5 publications with BCAN and ADAMTS4
 DCN recombinant protein  >2 publications with BCAN and DCN
 TNR recombinant protein  >2 publications with BCAN and TNR
 ADAMTS5 recombinant protein  >1 publications with BCAN and ADAMTS5

Pathways associated with BCAN recombinant protein

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway antibodies  Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram

Diseases associated with BCAN recombinant protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with BCAN and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >3 publications with BCAN and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with BCAN and Inflammation
 Lung Diseases Antibodies  >2 publications with BCAN and Lung Diseases
 Fibrosis Antibodies  >2 publications with BCAN and Fibrosis
 Lung Neoplasms Antibodies  >2 publications with BCAN and Lung Neoplasms
 Breast Neoplasms Antibodies  >2 publications with BCAN and Breast Neoplasms
 Hypertrophy Antibodies  >1 publications with BCAN and Hypertrophy
 Skin Neoplasms Antibodies  >1 publications with BCAN and Skin Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with BCAN and Congenital Abnormalities

Organs/Tissues associated with BCAN recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >70 publications with BCAN and Brain
 Embryonic Tissue Antibodies  >6 publications with BCAN and Embryonic Tissue
 Skin Antibodies  >2 publications with BCAN and Skin
 Kidney Antibodies  >1 publications with BCAN and Kidney
 Eye Antibodies  >1 publications with BCAN and Eye
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