CPNE1 Human Recombinant Protein

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

CPNE1: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. Belongs to the copine family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; endopeptidase activity; NF-kappaB binding; phosphatidylserine binding; protein binding; protein homodimerization activity; transporter activity

Biological Process: glycerophospholipid biosynthetic process; lipid metabolic process; negative regulation of DNA binding; positive regulation of neuron differentiation; positive regulation of protein kinase B signaling cascade; proteolysis; regulation of I-kappaB kinase/NF-kappaB cascade; vesicle-mediated transport