VCP Human Recombinant Protein

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

VCP: valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization.

Protein type: Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle; lipid particle; nucleoplasm; nucleus; perinuclear region of cytoplasm; proteasome complex

Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding

Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; ER-associated protein catabolic process; establishment of protein localization; NADH metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; unfolded protein response; viral genome replication

Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Charcot-marie-tooth Disease, Axonal, Type 2y; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1