Human Cellexp IFNA2 Active Protein – Cat# MBS844630

IFN-Alpha 2b (IFNA2) Human Cellexp Active Protein

Name: IFNA2 Active Protein; IFN-Alpha 2b; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844630
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844630

Background: Interferons (IFNs) are proteins made and released by host cells in response to the presence of pathogens. They belong to the large class of glycoproteins known as cytokines. IFN-alpha is produced by macrophages and has antiviral activities. IFNs… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IFN-alpha 2b (IFNA2), Active Protein

Full Product Name

Human CellExp IFN-alpha 2b, Human Recombinant

Product Gene Name

IFNA2 active protein

Product Synonym Names

Leukocyte interferon; B cell interferon; Type I interferon; IFNA2; IFN-alpha 2a.; Human Cellexp Human Recombinant IFN-alpha 2b

Host

Human 293 cell expressed

Form/Format

Lyophilized from a PBS solution.
Appearance: Lyophilized

Purity/Purification

>=95%

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

16 kDa, monomer, glycosylated

OMIM

147562

3D Structure

ModBase 3D Structure for P01563

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Endotoxin Level

< 1.0 EU per 1 mug of protein

Biological Activity

ED is typically 0.02 to 0.08 ng/mL. The specific activity was determined by the dose-dependent cytotoxicity of the human TF -1 cell line(human erythroleukemic indicator cell line).

Results

0.02 to 0.08 ng/ml

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for IFNA2 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; IFNsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z

Applications Tested/Suitable for IFNA2 active protein

SDS-PAGE

Other Notes

Small volumes of IFNA2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNA2 purchase

MBS844630 is an active protein targeting IFNA2. Also known as Human CellExp IFN-alpha 2b, Human Recombinant. Host: Human 293 cell expressed.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNA2. It may not necessarily be applicable to this product.

NCBI GI #

11067751

NCBI GeneID

3440

NCBI Accession #

NP_000596.2

UniProt Primary Accession #

P01563

UniProt Secondary Accession #

P01564; Q14606; Q6DJX8; Q96KI6; H2DF54; H2DF55

UniProt Related Accession #

P01563

GenBank Nucleotide #

NM_000605.3

NCBI Official Full Name

interferon alpha-2

NCBI Official Synonym Full Names

interferon, alpha 2

NCBI Official Symbol

IFNA2

NCBI Official Synonym Symbols

IFNA; INFA2; IFNA2B; IFN-alphaA

UniProt Protein Name

Interferon alpha-2

UniProt Synonym Protein Names

Interferon alpha-A; LeIF A

Protein Family

C-type lectin domain family

UniProt Gene Name

IFNA2

UniProt Synonym Gene Names

IFNA2A; IFNA2B; IFNA2C; IFN-alpha-2; LeIF A

UniProt Entry Name

IFNA2_HUMAN

NCBI Protein Information

interferon alpha-2

NCBI Summary for IFNA2

This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

UniProt Comments for IFNA2

IFNA2: Produced by macrophages, IFN-alpha have antiviral activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted; Membrane protein, integral; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; interferon-alpha/beta receptor binding; cytokine activity

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of virion penetration into host cell; apoptosis; cytokine and chemokine mediated signaling pathway; innate immune response; negative regulation of transcription, DNA-dependent; blood coagulation; inflammatory response; defense response to virus; negative regulation of T cell differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein

Research Articles on IFNA2

1. Therefore, this study associated, for the first time, in a large panel of pancreatic cancer cell lines the effects of IFN-alpha/-beta with the expression of type-I IFN receptors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNA2 active protein

Reference Product	PubMed Publications
IFNAR1 active protein	>428 publications with IFNA2 and IFNAR1
STAT2 active protein	>291 publications with IFNA2 and STAT2
IFNAR2 active protein	>212 publications with IFNA2 and IFNAR2
JAK1 active protein	>172 publications with IFNA2 and JAK1
TYK2 active protein	>162 publications with IFNA2 and TYK2
IRF1 active protein	>122 publications with IFNA2 and IRF1
IRF2 active protein	>44 publications with IFNA2 and IRF2
IFNG active protein	>23 publications with IFNA2 and IFNG
IL28RA active protein	>1 publications with IFNA2 and IL28RA

Diseases associated with IFNA2 active protein

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>2556 publications with IFNA2 and Skin Diseases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies	>1420 publications with IFNA2 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Carcinoma, Renal Cell Antibodies	>1418 publications with IFNA2 and Carcinoma, Renal Cell
Anemia Antibodies	>922 publications with IFNA2 and Anemia
Fever Antibodies	>803 publications with IFNA2 and Fever
Lymphoma, Non-Hodgkin Antibodies	>711 publications with IFNA2 and Lymphoma, Non-Hodgkin
Neutropenia Antibodies	>666 publications with IFNA2 and Neutropenia
Fatigue Antibodies	>664 publications with IFNA2 and Fatigue
Mental Disorders Antibodies	>646 publications with IFNA2 and Mental Disorders
Thrombocytopenia Antibodies	>625 publications with IFNA2 and Thrombocytopenia