IL28RA Blocking Peptide (Center) Blocking Peptide

Name: IL28RA Blocking Peptide (Center) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9229983
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9229983

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL28RA (IFNLR1), Blocking Peptide

Full Product Name

IL28RA Blocking Peptide (Center)

Product Gene Name

IFNLR1 blocking peptide

Product Synonym Gene Name

IL28RA; LICR2

Product Synonym Names

Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IL28RA; LICR2

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence is selected from aa 387-400 of HUMAN IFNLR1

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

IL28RA peptide (MBS9229983) is used for blocking the activity of IL28RA antibody (MBS9214817)

Molecular Weight

27,536 Da

OMIM

607404

Cellular Location

Membrane; Single-pass type I membrane protein

Tissue Location

Widely expressed.

Other Notes

Small volumes of IFNLR1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNLR1 purchase

MBS9229983 is a blocking peptide targeting IFNLR1. Also known as IL28RA Blocking Peptide (Center).

Additional Details

NCBI/Uniprot data below describe general gene information for IFNLR1. It may not necessarily be applicable to this product.

NCBI GI #

55976528

NCBI GeneID

163702

NCBI Accession #

Q8IU57.1

UniProt Primary Accession #

Q8IU57

UniProt Secondary Accession #

Q5VTX5; Q5VTX7; Q5VTX8; Q6ZML8; Q8IV66; Q8IZI7; Q8IZI8

UniProt Related Accession #

Q8IU57

NCBI Official Full Name

Interferon lambda receptor 1

NCBI Official Synonym Full Names

interferon lambda receptor 1

NCBI Official Symbol

IFNLR1

NCBI Official Synonym Symbols

IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1

UniProt Protein Name

Interferon lambda receptor 1

UniProt Synonym Protein Names

Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2

Protein Family

Interferon lambda receptor

UniProt Gene Name

IFNLR1

UniProt Synonym Gene Names

IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2

UniProt Entry Name

INLR1_HUMAN

NCBI Protein Information

interferon lambda receptor 1

NCBI Summary for IFNLR1

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for IFNLR1

IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: interleukin-28 receptor complex; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host

Research Articles on IFNLR1

1. Polymorphism within the IL-28R1, but not in IL-28B, is associated with benign prostatic hyperplasia and lower urinary tract symptoms in Chinese.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IFNLR1 blocking peptide

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram
Type III Interferon Signaling Pathway antibodies	Type III Interferon Signaling Pathway Diagram

Diseases associated with IFNLR1 blocking peptide

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>7 publications with IFNLR1 and Liver Diseases
Lung Diseases Antibodies	>3 publications with IFNLR1 and Lung Diseases
Nervous System Diseases Antibodies	>2 publications with IFNLR1 and Nervous System Diseases
Liver Cirrhosis Antibodies	>1 publications with IFNLR1 and Liver Cirrhosis
Carcinoma Antibodies	>1 publications with IFNLR1 and Carcinoma
Fibrosis Antibodies	>1 publications with IFNLR1 and Fibrosis
Fatty Liver Antibodies	>1 publications with IFNLR1 and Fatty Liver
Carcinoma, Hepatocellular Antibodies	>1 publications with IFNLR1 and Carcinoma, Hepatocellular
Lung Neoplasms Antibodies	>1 publications with IFNLR1 and Lung Neoplasms
Hyperplasia Antibodies	>1 publications with IFNLR1 and Hyperplasia

Organs/Tissues associated with IFNLR1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with IFNLR1 and Lung
Lymph Antibodies	>2 publications with IFNLR1 and Lymph
Lymph Node Antibodies	>2 publications with IFNLR1 and Lymph Node
Intestine Antibodies	>1 publications with IFNLR1 and Intestine
Prostate Antibodies	>1 publications with IFNLR1 and Prostate