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A-893 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5802878

MBS5802878 is an inhibitor targeting A-893. A-893 is a cell-active Inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
A-893, Inhibitor
Full Product Name
A-893
Product Gene Name
A-893, inhibitor
Preparation and Storage
Powder: -20 degree C for 3 years | In solvent: -80 degree C for 1 year
Molecular Weight
577.54
SMILES
[C@@H](CNCCN(C(CCNCCC1=CC(Cl)=C(Cl)C=C1)=O)C2CCCCC2)(O)C3=C4C(NC(=O)CO4)=CC=C3
Formula
C29H38Cl2N4O4
Solubility
(< 1 mg/ml refers to the product slightly soluble or insoluble)
CAS Number
1868232-32-9
In_vitro
As expected, the ratio of p53K370me1 to overall p53 levels is reduced by treatment with either A-893 or AZ505. While this unexpectedly depicts a more robust response with AZ505, further dissection of the data provides clarity into the origin of this. While overall p53 levels are unaffected by A-893, a surprising >3-fold increase is observed with AZ505. Analysis of p53K370me1 levels reveals that Inhibitor A-893 exhibited 42% reduction in the methyl mark, while AZ-505 is slightly less effective at 28% reduction [1].

Structure of A-893, inhibitor

A-893 Inhibitor – Cat# MBS5802878

Other Notes

Small volumes of A-893, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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