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Adibendan Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5773404

MBS5773404 is an inhibitor targeting Adibendan. Adibendan is a selective inhibitor of PDE3 with an IC50 of 2.0uM. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adibendan, Inhibitor
Full Product Name
Adibendan
Product Synonym Names
AdibendauM
Purity/Purification
98%
Preparation and Storage
Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years
Molecular Weight
278.315
SMILES
CC1(C)C(=O)Nc2cc3nc([nH]c3cc12)-c1ccncc1
Formula
C16H14N4O
CAS Number
100510-33-6
Solubility
(<1mg/mL refers to the product slightly soluble or insoluble)
In_vitro
Adibendan exerted a concentration-dependent (0.03 -300uM) positive inotropic effect in papillary muscles (EC50 = 1.3uM) which was only partially reversible. The IC50 values for the inhibition of PDE1 or PDE2 were more than 60-fold higher[1].

Structure of Adibendan, inhibitor

Adibendan, CAS 100510-33-6
Adibendan Inhibitor – Cat# MBS5773404

Structure of Adibendan, inhibitor

Adibendan, CAS 100510-33-6
Adibendan Inhibitor, Structure – Cat# MBS5773404

Product References and Citations for Adibendan, inhibitor

1 Bethk T e al Mechanis o actio an cardiotoni activit o ne phosphodiesteras inhibitor th benzimidazol derivativ adibenda (B 14.478) i guinea-pi hearts Nauny Schmiedeberg Arc Pharmacol 198 May 37(5):576-82.
2 vo de Leye H e al Mechanis underlyin th reduce positiv inotropi effect o th phosphodiesteras II inhibitor pimobendan adibenda an saterinon i failin a compare t nonfailin PUMA cardia muscl preparations Nauny Schmiedeberg Arc Pharmacol 199 Jul 44(1):90-100.
3 Reif K High-performanc liqui chromatographi metho fo th determinatio o adibenda i plasm an urine Chromatogr 198 No 27 22:346-52.
4 Peter P e al Zentral Hämodynami unte de neue positi inotrope Substan Adibendan Date eine Dosisfindungsstudi [Centra hemodynamic o ne positiv inotropi substance adibendan Dat fro dose-findin stud] Arzneimittelforschung 199 Jun 0(6):666-8 German.

Other Notes

Small volumes of Adibendan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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