Atuveciclib Inhibitor

Name: Atuveciclib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752764
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752764

Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb/CDK9 inhibitor. It inhibits CDK9/CycT1 (IC50: 13nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Atuveciclib, Inhibitor

Full Product Name

Atuveciclib

Product Synonym Names

BAY-1143572

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

387.43

Solubility

DMSO: 128.5mg/mL (331.67mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H18FN5O2S

SMILES

N=[S@](CC1=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=CC=C1)(C)=O

Target & IC50

CDK9/CycT1: ic50 6nM
CDK3/CycE: ic50 890nM
CDK2/CycE: ic50 1000nM
CDK1/CycB: ic50 1100nM
CDK5/p35: ic50 1600nM

In Vitro

Positive transcription elongation factor b (PTEFb) is a heterodimer of CDK9 and one of four cyclin partners, cyclin T1, cyclin K, cyclin T2a, or cyclin T2b. Atuveciclib demonstrates potent antiproliferative activity against HeLa cells (IC50: 920nM) and MOLM-13 cells (IC50: 310nM).

Product Categories/Family for Atuveciclib, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for Atuveciclib, inhibitor

Lucking U, et al. Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the treatment,of Cancer. ChemMedChem. 2017 Nov 8;12(21):1776-1793.
Lucking U, et al. Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the treatment,of Cancer. ChemMedChem. 2017 Nov 8;12(21):1776-1793.

Other Notes

Small volumes of Atuveciclib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Atuveciclib purchase

MBS5752764 is an inhibitor targeting Atuveciclib.