Aurantiamide Inhibitor

Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-kappaB, JNK and p38 pathways.

1. 1. Yoon C S, Kim D C, Lee D S, et al. Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-kappaB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells[J]. International Immunopharmacology, 2014, 23 (2):568-574.
2. Zhou B, Yang Z, Feng Q, et al. Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-kappaB signaling pathway in Influenza A virus-infected cells[J]. Journal of Ethnopharmacology, 2017, 199:60-67.

Small volumes of Aurantiamide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5752161 is an inhibitor targeting Aurantiamide.