BBIQ Inhibitor

98.02%

Powder: -2 degree C for 3 years
In solvent: -80 degree C for 2 years

330.435

CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccccc1

C21H22N4

1229024-57-0

TLR
TLR7: 59.1nM (EC50)(Human TLR7)

(<1mg/mL refers to the product slightly soluble or insoluble)

In mice treated with Chloroquine (CQ) alone, parasite (P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ?+?CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. serum levels of IFN-gamma and IL-12 are higher on same day in mice treated with BBIQ?+?CQ which reveals the generation of strong Th1 immune response in mice against the infection[1]. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy.